2YFE

Ligand binding domain of human PPAR gamma in complex with amorfrutin 1

Summary for 2YFE

Entry DOI	10.2210/pdb2yfe/pdb
Related	1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZGY 2F4B 2FVJ 2G0G 2G0H 2PRG 2VSR 2VST 2VV0 2VV1 2VV2 2VV3 2VV4 2XKW 3PRG 4PRG
Descriptor	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, Amorfrutin 1 (3 entities in total)
Functional Keywords	receptor, agonist, diabetes, insulin resistance
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	66068.47
Authors	de Groot, J.C.,Buessow, K. (deposition date: 2011-04-05, release date: 2012-04-11, Last modification date: 2023-12-20)
Primary citation	Weidner, C.,De Groot, J.C.,Prasad, A.,Freiwald, A.,Quedenau, C.,Kliem, M.,Witzke, A.,Kodelja, V.,Han, C.-T.,Giegold, S.,Baumann, M.,Klebl, B.,Siems, K.,Mueller-Kuhrt, L.,Schuermann, A.,Schueller, R.,Pfeiffer, A.F.H.,Schroeder, F.C.,Buessow, K.,Sauer, S. Amorfrutins are Potent Antidiabetic Dietary Natural Products Proc.Natl.Acad.Sci.USA, 109:7257-, 2012 Cited by PubMed: 22509006 DOI: 10.1073/PNAS.1116971109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation