Author results

3ROV
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2011-04-26
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
1JCA
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NON-STANDARD DESIGN OF UNSTABLE INSULIN ANALOGUES WITH ENHANCED ACTIVITY
Descriptor:insulin a, insulin b, ZINC ION
Authors:Weiss, M.A., Wan, Z., Zhao, M., Chu, Y.-C., Nakagawa, S.H., Burke, G.T., Jia, W., Hellmich, R., Katsoyannis, P.G.
Deposit date:2001-06-08
Release date:2001-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
3JSD
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2009-09-10
Release date:2010-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
1J73
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CRYSTAL STRUCTURE OF AN UNSTABLE INSULIN ANALOG WITH NATIVE ACTIVITY.
Descriptor:insulin a, insulin b, ZINC ION
Authors:Wan, Z., Zhao, M., Nakagawa, S., Jia, W., Weiss, M.A.
Deposit date:2001-05-15
Release date:2001-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
1LKQ
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NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-GLY, VAL-A3-GLY, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:INSULIN
Authors:Weiss, M.A., Hua, Q.X., Chu, Y.C., Jia, W., Philips, N.F., Wang, R.Y., Katsoyannis, P.G.
Deposit date:2002-04-25
Release date:2002-05-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing
J.Biol.Chem., 277, 2002
1SF1
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NMR STRUCTURE OF HUMAN INSULIN UNDER AMYLOIDOGENIC CONDITION, 15 STRUCTURES
Descriptor:INSULIN A CHAIN, Insulin
Authors:Weiss, M.A., Hua, Q.X.
Deposit date:2004-02-19
Release date:2004-03-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate
J.Biol.Chem., 279, 2004
1ZV1
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CRYSTAL STRUCTURE OF THE DIMERIZATION DOMAIN OF DOUBLESEX PROTEIN FROM D. MELANOGASTER
Descriptor:Doublesex protein
Authors:Weiss, M.A., Bayrer, J.R., Wan, Z., Li, B., Phillips, N.B.
Deposit date:2005-06-01
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation
J.Biol.Chem., 280, 2005
2LWZ
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NMR STRUCTURES OF SINGLE-CHAIN INSULIN
Descriptor:SINGLE-CHAIN INSULIN
Authors:Weiss, M.A., Yang, Y.
Deposit date:2012-08-09
Release date:2013-08-28
Method:SOLUTION NMR
Cite:Dynamic repair of an amyloidogenic protein: Insulin fibrillation is blocked by tethering a nascent alpha-helix
To be Published
1Q4V
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CRYSTAL STRUCTURE OF ALLO-ILEA2-INSULIN, AN INACTIVE CHIRAL ANALOGUE: IMPLICATIONS FOR THE MECHANISM OF RECEPTOR
Descriptor:Insulin, ZINC ION, PHENOL
Authors:Wan, Z.L., Xu, B., Chu, Y.C., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2003-08-04
Release date:2003-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding.
Biochemistry, 42, 2003
3P2X
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIARAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIRAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3V19
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V1G
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, PHENOL, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
1HIQ
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PARADOXICAL STRUCTURE AND FUNCTION IN A MUTANT HUMAN INSULIN ASSOCIATED WITH DIABETES MELLITUS
Descriptor:INSULIN
Authors:Hua, Q.X., Shoelson, S.E., Inouye, K., Weiss, M.A.
Deposit date:1993-03-05
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
Proc.Natl.Acad.Sci.USA, 90, 1993
1KMF
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NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALLO-ILE, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:Insulin
Authors:Xu, B., Hua, Q.X., Nakagawa, S.H., Jia, W., Chu, Y.C., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2001-12-14
Release date:2002-01-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.
J.Mol.Biol., 316, 2002
1QYP
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THERMOCOCCUS CELER RPB9, NMR, 25 STRUCTURES
Descriptor:RNA POLYMERASE II, ZINC ION
Authors:Wang, B., Jones, D.N.M., Kaine, B.P., Weiss, M.A.
Deposit date:1997-08-19
Release date:1997-12-24
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:High-resolution structure of an archaeal zinc ribbon defines a general architectural motif in eukaryotic RNA polymerases.
Structure, 6, 1998
1RWE
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ENHANCING THE ACTIVITY OF INSULIN AT RECEPTOR EDGE: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING OF A8 ANALOGUES
Descriptor:insulin, Insulin, ZINC ION, ...
Authors:Wan, Z., Xu, B., Chu, Y.C., Li, B., Nakagawa, S.H., Qu, Y., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2003-12-16
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004
5ZNF
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ALTERNATING ZINC FINGERS IN THE HUMAN MALE ASSOCIATED PROTEIN ZFY: 2D NMR STRUCTURE OF AN EVEN FINGER AND IMPLICATIONS FOR "JUMPING-LINKER" DNA RECOGNITION
Descriptor:ZINC FINGER, ZINC ION
Authors:Kochoyan, M., Keutmann, H.T., Weiss, M.A.
Deposit date:1991-08-22
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition.
Biochemistry, 30, 1991
7ZNF
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ALTERNATING ZINC FINGERS IN THE HUMAN MALE ASSOCIATED PROTEIN ZFY: 2D NMR STRUCTURE OF AN EVEN FINGER AND IMPLICATIONS FOR "JUMPING-LINKER" DNA RECOGNITION
Descriptor:ZINC FINGER, ZINC ION
Authors:Kochoyan, M., Keutmann, H.T., Weiss, M.A.
Deposit date:1991-08-22
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition.
Biochemistry, 30, 1991
1HIS
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STRUCTURE AND DYNAMICS OF DES-PENTAPEPTIDE-INSULIN IN SOLUTION: THE MOLTEN-GLOBULE HYPOTHESIS.
Descriptor:INSULIN
Authors:Hua, Q.X., Kochoyan, M., Weiss, M.A.
Deposit date:1992-02-28
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and dynamics of des-pentapeptide-insulin in solution: the molten-globule hypothesis.
Proc.Natl.Acad.Sci.USA, 89, 1992
1JB6
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CRYSTAL STRUCTURE OF DIMERIZATION DOMAIN (1-33) OF HNF-1ALPHA
Descriptor:HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
Authors:Narayana, N., Hua, Q.-X., Weiss, M.A.
Deposit date:2001-06-01
Release date:2001-07-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The dimerization domain of HNF-1alpha: structure and plasticity of an intertwined four-helix bundle with application to diabetes mellitus.
J.Mol.Biol., 310, 2001
1KLR
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NMR STRUCTURE OF THE ZFY-6T[Y10F] ZINC FINGER
Descriptor:ZINC FINGER Y-CHROMOSOMAL PROTEIN, ZINC ION
Authors:Lachenmann, M.J., Ladbury, J.E., Phillips, N.B., Narayana, N., Qian, X., Weiss, M.A.
Deposit date:2001-12-12
Release date:2002-03-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The hidden thermodynamics of a zinc finger.
J.Mol.Biol., 316, 2002
1XGL
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HUMAN INSULIN DISULFIDE ISOMER, NMR, 10 STRUCTURES
Descriptor:INSULIN
Authors:Hua, Q.X., Gozani, S.N., Chance, R.E., Hoffmann, J.A., Frank, B.H., Weiss, M.A.
Deposit date:1996-10-10
Release date:1997-04-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a protein in a kinetic trap.
Nat.Struct.Biol., 2, 1995
2HIU
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NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES
Descriptor:INSULIN
Authors:Hua, Q.X., Gozani, S.N., Chance, R.E., Hoffmann, J.A., Frank, B.H., Weiss, M.A.
Deposit date:1996-10-08
Release date:1997-04-01
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structure of a protein in a kinetic trap.
Nat.Struct.Biol., 2, 1995
3BXQ
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THE STRUCTURE OF A MUTANT INSULIN UNCOUPLES RECEPTOR BINDING FROM PROTEIN ALLOSTERY. AN ELECTROSTATIC BLOCK TO THE TR TRANSITION
Descriptor:insulin A chain, insulin B chain, ZINC ION
Authors:Wan, Z.L., Huang, K., Hu, S.Q., Whittaker, J., Weiss, M.A.
Deposit date:2008-01-14
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008