NMR Structure of Proinsulin

Summary for 2KQP

DescriptorInsulin (1 entity in total)
Functional Keywordsproinsulin, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, disulfide bond, glucose metabolism, hormone, pharmaceutical, secreted
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308
Total number of polymer chains1
Total molecular weight9379.58
Yang, Y.,Hua, Q.X.,Mackin, R.B.,Weiss, M.A. (deposition date: 2009-11-12, release date: 2010-01-26, Last modification date: 2011-07-13)
Primary citation
Yang, Y.,Hua, Q.X.,Liu, J.,Shimizu, E.H.,Choquette, M.H.,Mackin, R.B.,Weiss, M.A.
Solution structure of proinsulin: connecting domain flexibility and prohormone processing.
J.Biol.Chem., 285:7847-7851, 2010
PubMed: 20106974 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.C109.084921
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers252.7%8.6%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures