2KQP

NMR Structure of Proinsulin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0001819	biological_process	positive regulation of cytokine production
A	0002020	molecular_function	protease binding
A	0002674	biological_process	negative regulation of acute inflammatory response
A	0005158	molecular_function	insulin receptor binding
A	0005159	molecular_function	insulin-like growth factor receptor binding
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005796	cellular_component	Golgi lumen
A	0006006	biological_process	glucose metabolic process
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006521	biological_process	regulation of cellular amino acid metabolic process
A	0006953	biological_process	acute-phase response
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007267	biological_process	cell-cell signaling
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008286	biological_process	insulin receptor signaling pathway
A	0010628	biological_process	positive regulation of gene expression
A	0010629	biological_process	negative regulation of gene expression
A	0010750	biological_process	positive regulation of nitric oxide mediated signal transduction
A	0010976	biological_process	positive regulation of neuron projection development
A	0022898	biological_process	regulation of transmembrane transporter activity
A	0030133	cellular_component	transport vesicle
A	0030307	biological_process	positive regulation of cell growth
A	0030335	biological_process	positive regulation of cell migration
A	0031904	cellular_component	endosome lumen
A	0031954	biological_process	positive regulation of protein autophosphorylation
A	0032148	biological_process	activation of protein kinase B activity
A	0032880	biological_process	regulation of protein localization
A	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
A	0033861	biological_process	negative regulation of NAD(P)H oxidase activity
A	0034774	cellular_component	secretory granule lumen
A	0038060	biological_process	nitric oxide-cGMP-mediated signaling
A	0042060	biological_process	wound healing
A	0042177	biological_process	negative regulation of protein catabolic process
A	0042311	biological_process	vasodilation
A	0042593	biological_process	glucose homeostasis
A	0042802	molecular_function	identical protein binding
A	0043410	biological_process	positive regulation of MAPK cascade
A	0045597	biological_process	positive regulation of cell differentiation
A	0045721	biological_process	negative regulation of gluconeogenesis
A	0045725	biological_process	positive regulation of glycogen biosynthetic process
A	0045818	biological_process	negative regulation of glycogen catabolic process
A	0045821	biological_process	positive regulation of glycolytic process
A	0045840	biological_process	positive regulation of mitotic nuclear division
A	0045861	biological_process	negative regulation of proteolysis
A	0045922	biological_process	negative regulation of fatty acid metabolic process
A	0046326	biological_process	positive regulation of glucose import
A	0046628	biological_process	positive regulation of insulin receptor signaling pathway
A	0046631	biological_process	alpha-beta T cell activation
A	0046889	biological_process	positive regulation of lipid biosynthetic process
A	0048167	biological_process	regulation of synaptic plasticity
A	0050708	biological_process	regulation of protein secretion
A	0050709	biological_process	negative regulation of protein secretion
A	0050714	biological_process	positive regulation of protein secretion
A	0050890	biological_process	cognition
A	0050995	biological_process	negative regulation of lipid catabolic process
A	0051000	biological_process	positive regulation of nitric-oxide synthase activity
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051247	biological_process	positive regulation of protein metabolic process
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0055089	biological_process	fatty acid homeostasis
A	0060266	biological_process	negative regulation of respiratory burst involved in inflammatory response
A	0060267	biological_process	positive regulation of respiratory burst
A	0090277	biological_process	positive regulation of peptide hormone secretion
A	0090336	biological_process	positive regulation of brown fat cell differentiation
A	1900182	biological_process	positive regulation of protein localization to nucleus
A	1900273	biological_process	positive regulation of long-term synaptic potentiation
A	1901701	biological_process	cellular response to oxygen-containing compound
A	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A	1902952	biological_process	positive regulation of dendritic spine maintenance
A	1903076	biological_process	regulation of protein localization to plasma membrane
A	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
A	1990535	biological_process	neuron projection maintenance
A	2000252	biological_process	negative regulation of feeding behavior

Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCTSiCSlyqLenyC

Chain	Residue	Details
A	CYS71-CYS85

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