PDB: 882 件ウェブページステータス検索Chemie searchBIRD

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8JLR	A77636-bound hTAAR1-Gs protein complex 分子名称: (1~{S},3~{R})-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1~{H}-isochromene-5,6-diol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. 登録日 2023-06-02 公開日 2023-11-15 最終更新日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature, 624, 2023
7CFN	Cryo-EM structure of the INT-777-bound GPBAR-Gs complex 分子名称: (2S,4R)-4-[(3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-ethyl-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-pentanoic acid, CHOLESTEROL, G-protein coupled bile acid receptor 1, ... 著者 Yang, F, Mao, C, Guo, L, Lin, J, Ming, Q, Xiao, P, Wu, X, Shen, Q, Guo, S, Shen, D, Lu, R, Zhang, L, Huang, S, Ping, Y, Zhang, C, Ma, C, Zhang, K, Liang, X, Shen, Y, Nan, F, Yi, F, Luca, V, Zhou, J, Jiang, C, Sun, J, Xie, X, Yu, X, Zhang, Y. 登録日 2020-06-27 公開日 2020-09-09 最終更新日 2021-04-07 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis of GPBAR activation and bile acid recognition. Nature, 587, 2020
8JGG	CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22 分子名称: BAM8-22, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Sun, J.P, Xu, H.E, Ynag, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. 登録日 2023-05-20 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023
8W89	Cryo-EM structure of the PEA-bound TAAR1-Gs complex 分子名称: 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. 登録日 2023-09-01 公開日 2023-11-22 最終更新日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
8W8B	Cryo-EM structure of SEP-363856 bounded serotonin 1A (5-HT1A) receptor-Gi protein complex 分子名称: 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Antibody fragment scFv16, CHOLESTEROL, ... 著者 Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. 登録日 2023-09-01 公開日 2023-11-22 最終更新日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
8G05	Cryo-EM structure of an orphan GPCR-Gi protein signaling complex 分子名称: 6-(octylamino)pyrimidine-2,4(3H,5H)-dione, CHOLESTEROL, G-protein coupled receptor 84, ... 著者 Zhang, X, Wang, Y.J, Li, X, Liu, G.B, Gong, W.M, Zhang, C. 登録日 2023-01-31 公開日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Pro-phagocytic function and structural basis of GPR84 signaling. Nat Commun, 14, 2023
7CMU	Dopamine Receptor D3R-Gi-Pramipexole complex 分子名称: (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, P, Huang, S, Mao, C, Krumm, B, Zhou, X, Tan, Y, Huang, X.-P, Liu, Y, Shen, D.-D, Jiang, Y, Yu, X, Jiang, H, Melcher, K, Roth, B, Cheng, X, Zhang, Y, Xu, H. 登録日 2020-07-29 公開日 2021-03-10 最終更新日 2021-04-07 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structures of the human dopamine D3 receptor-G i complexes. Mol.Cell, 81, 2021
8JBF	Senktide bound to active human neurokinin 3 receptor in complex with Gq 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein Gq subunit alpha, ... 著者 Sun, W.J, Yang, F, Zhang, H.H, Yuan, Q.N, Yin, W.C, Shi, P, Eric, X, Tian, C.L. 登録日 2023-05-08 公開日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists. Cell Discov, 9, 2023
8JT6	5-HT1A-Gi in complex with compound (R)-IHCH-7179 分子名称: 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Chen, Z, Xu, P, Huang, S, Xu, H.E, Wang, S. 登録日 2023-06-21 公開日 2024-02-28 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 187, 2024
8WC3	Cryo-EM structure of the SEP363856-bound mTAAR1-Gs complex 分子名称: 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. 登録日 2023-09-11 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
6NBF	Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein 分子名称: CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. 登録日 2018-12-07 公開日 2019-04-17 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure and dynamics of the active human parathyroid hormone receptor-1. Science, 364, 2019
7YS6	Cryo-EM structure of the Serotonin 6 (5-HT6) receptor-DNGs-scFv16 complex 分子名称: 5-hydroxytryptamine receptor 6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhao, Q.Y, Wang, Y.F, He, L, Wang, S, Cong, Y. 登録日 2022-08-11 公開日 2023-03-29 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into constitutive activity of 5-HT 6 receptor. Proc.Natl.Acad.Sci.USA, 120, 2023
7XXI	Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi 分子名称: 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B. 登録日 2022-05-30 公開日 2023-06-07 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R. Protein Cell, 14, 2023
7YFC	Cryo-EM structure of the histamine-bound histamine H4 receptor and Gq complex 分子名称: CHOLESTEROL, Engineered G-alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Im, D, Iwata, S, Asada, H. 登録日 2022-07-08 公開日 2023-10-25 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into the agonists binding and receptor selectivity of human histamine H 4 receptor. Nat Commun, 14, 2023
6OSA	human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation (NC state) 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Kato, H.E, Zhang, Y, Kobilka, B.K, Skiniotis, G. 登録日 2019-05-01 公開日 2019-07-10 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Conformational transitions of a neurotensin receptor 1-Gi1complex. Nature, 572, 2019
6OS9	human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Kato, H.E, Zhang, Y, Kobilka, B.K, Skiniotis, G. 登録日 2019-05-01 公開日 2019-07-10 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Conformational transitions of a neurotensin receptor 1-Gi1complex. Nature, 572, 2019
6ORV	Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor 分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Belousoff, M.J, Liang, Y.L, Danev, R. 登録日 2019-05-01 公開日 2020-01-08 最終更新日 2020-01-29 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Activation of the GLP-1 receptor by a non-peptidic agonist. Nature, 577, 2020
7JVQ	Cryo-EM structure of apomorphine-bound dopamine receptor 1 in complex with Gs protein 分子名称: (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol, CHOLESTEROL, D(1A) dopamine receptor, ... 著者 Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. 登録日 2020-08-22 公開日 2021-02-24 最終更新日 2021-03-03 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell, 184, 2021
7JV5	Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein 分子名称: (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... 著者 Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. 登録日 2020-08-20 公開日 2021-02-24 最終更新日 2021-03-03 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell, 184, 2021
8H2G	Cryo-EM structure of niacin bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Park, J.H, Ishimoto, N, Park, S.Y. 登録日 2022-10-06 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structural basis for hydroxy-carboxylic acid receptor 2 activation and allosteric mechanism To Be Published
6P9Y	PAC1 GPCR Receptor complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. 登録日 2019-06-10 公開日 2020-02-05 最終更新日 2020-02-19 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation. Mol.Cell, 77, 2020
8HCQ	Cryo-EM structure of endothelin1-bound ETAR-Gq complex 分子名称: Endothelin-1, Endothelin-1 receptor,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Yuan, Q, Jiang, Y, Xu, H.E, Ji, Y, Duan, J. 登録日 2022-11-02 公開日 2023-03-22 最終更新日 2023-10-04 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structural basis of peptide recognition and activation of endothelin receptors. Nat Commun, 14, 2023
8HNK	CXCR3-DNGi complex activated by CXCL11 分子名称: C-X-C motif chemokine 11, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Jiao, H.Z, Hu, H.L. 登録日 2022-12-08 公開日 2023-11-29 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
7WKD	TRH-TRHR G protein complex 分子名称: Gq, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, Y, Cai, H, You, C, He, X, Yuan, Q, Jiang, H, Cheng, X, Jiang, Y, Xu, H.E. 登録日 2022-01-09 公開日 2022-06-15 最終更新日 2022-09-14 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor. Cell Res., 32, 2022
7XP4	Cryo-EM structure of a class T GPCR in apo state 分子名称: Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. 登録日 2022-05-03 公開日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022

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