8W8B

Cryo-EM structure of SEP-363856 bounded serotonin 1A (5-HT1A) receptor-Gi protein complex

Summary for 8W8B

• Entry DOI: 10.2210/pdb8w8b/pdb
• EMDB information: 37351
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Antibody fragment scFv16, ... (8 entities in total)
• Functional Keywords: 5-ht1a, sep363856, gpcr, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 177641.08

Authors

Liu, H.,Zheng, Y.,Wang, Y.,Wang, Y.,He, X.,Xu, P.,Huang, S.,Yuan, Q.,Zhang, X.,Wang, S.,Xu, H.E.,Xu, F. (deposition date: 2023-09-01, release date: 2023-11-22, Last modification date: 2024-01-03)

• Primary citation: Liu, H.,Zheng, Y.,Wang, Y.,Wang, Y.,He, X.,Xu, P.,Huang, S.,Yuan, Q.,Zhang, X.,Wang, L.,Jiang, K.,Chen, H.,Li, Z.,Liu, W.,Wang, S.,Xu, H.E.,Xu, F.; Recognition of methamphetamine and other amines by trace amine receptor TAAR1.; Nature, 624:663-671, 2023; PubMed: 37935377; DOI: 10.1038/s41586-023-06775-1

Experimental method

ELECTRON MICROSCOPY (3 Å)