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8W8B

Cryo-EM structure of SEP-363856 bounded serotonin 1A (5-HT1A) receptor-Gi protein complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440414.01UniProt (P63096)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34537915.51UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(E)		Antibody fragment scFv16polymer26728668.91Homo sapiens (human)
4D
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
5E
(R)		Soluble cytochrome b562,5-hydroxytryptamine receptor 1Apolymer54360408.51UniProt (P0ABE7)
UniProt (P08908)
Pfam (PF00001)		Escherichia coliCytochrome b-562,5-HT-1A,5-HT1A,G-21,Serotonin receptor 1A
6F, G, H, I, J
(R)		CHOLESTEROLnon-polymer386.75Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (18640088)
PubChem (1715243)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (1715244)
PubChem (23423981)
PubChem (45044259)
PubChem (638019)
PubChem (49853509)
PubChem (50990013)
PubChem (44654663)
PubChem (52934537)
PubChem (56621683)
PubChem (1549081)
PubChem (1553803)
PubChem (46937002)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (59274407)
PubChem (5283629)
PubChem (5284644)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (5315842)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (6419195)
PubChem (5997)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (1551269)
PubChem (90070115)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (117965027)
PubChem (6432564)
PubChem (101624109)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (138967089)
PubChem (139566851)
PubChem (130459183)
PubChem (131992107)
PubChem (15939944)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (171828367)
PubChem (173516975)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
7K
(R)		PALMITIC ACIDnon-polymer256.41Chemie (PLM)
8L
(R)		1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanaminenon-polymer183.31Chemie (UJL)
PubChem (68335002)
PubChem (89532773)
PubChem (89532783)
Sequence modifications
A: 1 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Asn 47Ser 47conflict
Ala 203Gly 203conflict
Ala 245Glu 245conflict
Ser 326Ala 326conflict
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -4-initiating methionine
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
R: -92 - 12 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Asp -120-expression tag
Tyr -119-expression tag
Lys -118-expression tag
Asp -117-expression tag
Asp -116-expression tag
Asp -115-expression tag
Asp -114-expression tag
Ala -113-expression tag
Lys -112-expression tag
Leu -111-expression tag
Gln -110-expression tag
Thr -109-expression tag
Met -108-expression tag
His -107-expression tag
His -106-expression tag
His -105-expression tag
His -104-expression tag
His -103-expression tag
His -102-expression tag
His -101-expression tag
His -100-expression tag
His -99-expression tag
His -98-expression tag
His -97-expression tag
His -96-expression tag
His -95-expression tag
His -94-expression tag
His -93-expression tag
Trp -86Met 29conflict
Ile 9His 124conflict
Leu 13-linker
Ala 14-linker
Ser 15-linker
Glu 16-linker
Asn 17-linker
Leu 18-linker
Tyr 19-linker
Phe 20-linker
Gln 21-linker
R: 22 - 422 (UniProt: P08908)
PDBExternal DatabaseDetails
Thr 24Asn 24conflict
Trp 125Leu 125conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight175268.1
Non-Polymers*Number of molecules7
Total formula weight2373.0
All*Total formula weight177641.1
*Water molecules are not included.

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PDB entries from 2026-04-01

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