7XXI

Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi

Summary for 7XXI

• Entry DOI: 10.2210/pdb7xxi/pdb
• EMDB information: 33504
• Descriptor: P2Y purinoceptor 12, Guanine nucleotide-binding protein G(i) subunit alpha-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total)
• Functional Keywords: g protein-coupled receptor, purinergic receptor, p2y12r, ligand binding, signal transduction, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 130748.18

Authors

Tan, Q.,Li, B.,Han, S.,Zhao, Q.,Wu, B. (deposition date: 2022-05-30, release date: 2023-06-07, Last modification date: 2023-09-20)

• Primary citation: Li, B.,Han, S.,Wang, M.,Yu, Y.,Ma, L.,Chu, X.,Tan, Q.,Zhao, Q.,Wu, B.; Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R.; Protein Cell, 14:382-386, 2023; PubMed: 37155313; DOI: 10.1093/procel/pwac025

Experimental method

ELECTRON MICROSCOPY (3 Å)