7CFN

Cryo-EM structure of the INT-777-bound GPBAR-Gs complex

Summary for 7CFN

• Entry DOI: 10.2210/pdb7cfn/pdb
• EMDB information: 30345
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (9 entities in total)
• Functional Keywords: gpcr, gpbar, complex, bile acid, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 142181.87

Authors

Yang, F.,Mao, C.,Guo, L.,Lin, J.,Ming, Q.,Xiao, P.,Wu, X.,Shen, Q.,Guo, S.,Shen, D.,Lu, R.,Zhang, L.,Huang, S.,Ping, Y.,Zhang, C.,Ma, C.,Zhang, K.,Liang, X.,Shen, Y.,Nan, F.,Yi, F.,Luca, V.,Zhou, J.,Jiang, C.,Sun, J.,Xie, X.,Yu, X.,Zhang, Y. (deposition date: 2020-06-27, release date: 2020-09-09, Last modification date: 2021-04-07)

• Primary citation: Yang, F.,Mao, C.,Guo, L.,Lin, J.,Ming, Q.,Xiao, P.,Wu, X.,Shen, Q.,Guo, S.,Shen, D.D.,Lu, R.,Zhang, L.,Huang, S.,Ping, Y.,Zhang, C.,Ma, C.,Zhang, K.,Liang, X.,Shen, Y.,Nan, F.,Yi, F.,Luca, V.C.,Zhou, J.,Jiang, C.,Sun, J.P.,Xie, X.,Yu, X.,Zhang, Y.; Structural basis of GPBAR activation and bile acid recognition.; Nature, 587:499-504, 2020; PubMed: 32698187; DOI: 10.1038/s41586-020-2569-1

Experimental method

ELECTRON MICROSCOPY (3 Å)