7YS6

Cryo-EM structure of the Serotonin 6 (5-HT6) receptor-DNGs-scFv16 complex

Summary for 7YS6

• Entry DOI: 10.2210/pdb7ys6/pdb
• EMDB information: 34073
• Descriptor: 5-hydroxytryptamine receptor 6, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, serotonin receptor, 5-ht6r, cryo-em, constitutive activity, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 152647.27

Authors

Zhao, Q.Y.,Wang, Y.F.,He, L.,Wang, S.,Cong, Y. (deposition date: 2022-08-11, release date: 2023-03-29, Last modification date: 2023-10-11)

• Primary citation: He, L.,Zhao, Q.Y.,Qi, J.,Wang, Y.,Han, W.,Chen, Z.,Cong, Y.,Wang, S.; Structural insights into constitutive activity of 5-HT 6 receptor.; Proc.Natl.Acad.Sci.USA, 120:e2209917120-e2209917120, 2023; PubMed: 36989299; DOI: 10.1073/pnas.2209917120

Experimental method

ELECTRON MICROSCOPY (3 Å)