7YS6
Cryo-EM structure of the Serotonin 6 (5-HT6) receptor-DNGs-scFv16 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5-hydroxytryptamine receptor 6 | polymer | 304 | 33201.9 | 1 | UniProt (P50406) Pfam (PF00001) | Homo sapiens (human) | 5-HT-6,5-HT6,Serotonin receptor 6 |
| 2 | B (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 357 | 39386.0 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (E) | scFv16 | polymer | 266 | 28636.8 | 1 | Mus musculus (mouse) | ||
| 5 | E (B) | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 373 | 43385.2 | 1 | UniProt (P63092-2) Pfam (PF00503) UniProt (by SIFTS) (P63092) | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
| 6 | F (A) | SEROTONIN | non-polymer | 176.2 | 1 | Chemie (SRO) |
Sequence modifications
A: 24 - 345 (UniProt: P50406)
C: 19 - 357 (UniProt: P62873)
B: 26 - 394 (UniProt: P63092-2)
| PDB | External Database | Details |
|---|---|---|
| - | Ser 231 | deletion |
| - | Gln 232 | deletion |
| - | Ala 233 | deletion |
| - | Ser 234 | deletion |
| - | Glu 235 | deletion |
| - | Thr 236 | deletion |
| - | Leu 237 | deletion |
| - | Gln 238 | deletion |
| - | Val 239 | deletion |
| - | Pro 240 | deletion |
| - | Arg 241 | deletion |
| - | Thr 242 | deletion |
| - | Pro 243 | deletion |
| - | Arg 244 | deletion |
| - | Pro 245 | deletion |
| - | Gly 246 | deletion |
| - | Val 247 | deletion |
| - | Glu 248 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| His 2 | - | expression tag |
| His 3 | - | expression tag |
| His 4 | - | expression tag |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| His 7 | - | expression tag |
| Glu 8 | - | expression tag |
| Asn 9 | - | expression tag |
| Leu 10 | - | expression tag |
| Tyr 11 | - | expression tag |
| Phe 12 | - | expression tag |
| Gln 13 | - | expression tag |
| Gly 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Gly 18 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 8 | - | initiating methionine |
| Gly 9 | - | expression tag |
| Cys 10 | - | expression tag |
| Thr 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Ser 13 | - | expression tag |
| Ala 14 | - | expression tag |
| Glu 15 | - | expression tag |
| Asp 16 | - | expression tag |
| Lys 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Ala 19 | - | expression tag |
| Val 20 | - | expression tag |
| Glu 21 | - | expression tag |
| Arg 22 | - | expression tag |
| Ser 23 | - | expression tag |
| Lys 24 | - | expression tag |
| Met 25 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 152471.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 176.2 | |
| All* | Total formula weight | 152647.3 |
