7YS6
Cryo-EM structure of the Serotonin 6 (5-HT6) receptor-DNGs-scFv16 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 5-hydroxytryptamine receptor 6 | polymer | 304 | 33201.9 | 1 | UniProt (P50406) Pfam (PF00001) In PDB | Homo sapiens (human) | 5-HT-6,5-HT6,Serotonin receptor 6 |
2 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 357 | 39386.0 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | D | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | E | scFv16 | polymer | 266 | 28636.8 | 1 | Mus musculus (mouse) | ||
5 | B | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 373 | 43385.2 | 1 | UniProt (P63092-2) In PDB | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
6 | A | SEROTONIN | non-polymer | 176.2 | 1 | Chemie (SRO) |
Sequence modifications
A: 24 - 345 (UniProt: P50406)
C: 19 - 357 (UniProt: P62873)
B: 26 - 394 (UniProt: P63092-2)
PDB | External Database | Details |
---|---|---|
- | Ser 231 | deletion |
- | Gln 232 | deletion |
- | Ala 233 | deletion |
- | Ser 234 | deletion |
- | Glu 235 | deletion |
- | Thr 236 | deletion |
- | Leu 237 | deletion |
- | Gln 238 | deletion |
- | Val 239 | deletion |
- | Pro 240 | deletion |
- | Arg 241 | deletion |
- | Thr 242 | deletion |
- | Pro 243 | deletion |
- | Arg 244 | deletion |
- | Pro 245 | deletion |
- | Gly 246 | deletion |
- | Val 247 | deletion |
- | Glu 248 | deletion |
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
His 2 | - | expression tag |
His 3 | - | expression tag |
His 4 | - | expression tag |
His 5 | - | expression tag |
His 6 | - | expression tag |
His 7 | - | expression tag |
Glu 8 | - | expression tag |
Asn 9 | - | expression tag |
Leu 10 | - | expression tag |
Tyr 11 | - | expression tag |
Phe 12 | - | expression tag |
Gln 13 | - | expression tag |
Gly 14 | - | expression tag |
Gly 15 | - | expression tag |
Ser 16 | - | expression tag |
Ser 17 | - | expression tag |
Gly 18 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 8 | - | initiating methionine |
Gly 9 | - | expression tag |
Cys 10 | - | expression tag |
Thr 11 | - | expression tag |
Leu 12 | - | expression tag |
Ser 13 | - | expression tag |
Ala 14 | - | expression tag |
Glu 15 | - | expression tag |
Asp 16 | - | expression tag |
Lys 17 | - | expression tag |
Ala 18 | - | expression tag |
Ala 19 | - | expression tag |
Val 20 | - | expression tag |
Glu 21 | - | expression tag |
Arg 22 | - | expression tag |
Ser 23 | - | expression tag |
Lys 24 | - | expression tag |
Met 25 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 152471.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 176.2 | |
All* | Total formula weight | 152647.3 |