8WC3

Cryo-EM structure of the SEP363856-bound mTAAR1-Gs complex

Summary for 8WC3

Entry DOI	10.2210/pdb8wc3/pdb
EMDB information	37429
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Trace amine-associated receptor 1, ... (6 entities in total)
Functional Keywords	sep363856, mtaar1, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	155990.20
Authors	Rong, N.K.,Guo, L.L.,Zhang, M.H.,Li, Q.,Yang, F.,Sun, J.P. (deposition date: 2023-09-11, release date: 2023-12-27)
Primary citation	Shang, P.,Rong, N.,Jiang, J.J.,Cheng, J.,Zhang, M.H.,Kang, D.,Qi, L.,Guo, L.,Yang, G.M.,Liu, Q.,Zhou, Z.,Li, X.B.,Zhu, K.K.,Meng, Q.B.,Han, X.,Yan, W.,Kong, Y.,Yang, L.,Wang, X.,Lei, D.,Feng, X.,Liu, X.,Yu, X.,Wang, Y.,Li, Q.,Shao, Z.H.,Yang, F.,Sun, J.P. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186:5347-5362.e24, 2023 Cited by PubMed: 37963465 DOI: 10.1016/j.cell.2023.10.014 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation