8WC3
Cryo-EM structure of the SEP363856-bound mTAAR1-Gs complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 362 | 42010.7 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) UniProt (by SIFTS) (P63096) In PDB | Homo sapiens (human) | |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | R | Trace amine-associated receptor 1 | polymer | 332 | 37656.6 | 1 | UniProt (Q923Y8) Pfam (PF00001) In PDB | Mus musculus (house mouse) | TaR-1,Trace amine receptor 1 |
4 | S | scFv16 | polymer | 285 | 30363.0 | 1 | synthetic construct | ||
5 | Y | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
6 | R | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine | non-polymer | 183.3 | 1 | Chemie (UJL) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Met -4 | - | initiating methionine |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 155806.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 183.3 | |
All* | Total formula weight | 155990.2 |