6ORV

Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor

This is a non-PDB format compatible entry.

Summary for 6ORV

• Entry DOI: 10.2210/pdb6orv/pdb
• EMDB information: 20179
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: g-coupled protein receptor, gpcr, non-peptide angonist, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 164824.63

Authors

Belousoff, M.J.,Liang, Y.L.,Danev, R. (deposition date: 2019-05-01, release date: 2020-01-08, Last modification date: 2020-01-29)

• Primary citation: Zhao, P.,Liang, Y.L.,Belousoff, M.J.,Deganutti, G.,Fletcher, M.M.,Willard, F.S.,Bell, M.G.,Christe, M.E.,Sloop, K.W.,Inoue, A.,Truong, T.T.,Clydesdale, L.,Furness, S.G.B.,Christopoulos, A.,Wang, M.W.,Miller, L.J.,Reynolds, C.A.,Danev, R.,Sexton, P.M.,Wootten, D.; Activation of the GLP-1 receptor by a non-peptidic agonist.; Nature, 577:432-436, 2020; PubMed: 31915381; DOI: 10.1038/s41586-019-1902-z

Experimental method

ELECTRON MICROSCOPY (3 Å)