Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ORV

Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AP	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
AP	0003091	biological_process	renal water homeostasis
AP	0003924	molecular_function	GTPase activity
AP	0003925	molecular_function	G protein activity
AP	0005515	molecular_function	protein binding
AP	0005525	molecular_function	GTP binding
AP	0005737	cellular_component	cytoplasm
AP	0005829	cellular_component	cytosol
AP	0005834	cellular_component	heterotrimeric G-protein complex
AP	0005886	cellular_component	plasma membrane
AP	0007165	biological_process	signal transduction
AP	0007186	biological_process	G protein-coupled receptor signaling pathway
AP	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
AP	0007190	biological_process	activation of adenylate cyclase activity
AP	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
AP	0007608	biological_process	sensory perception of smell
AP	0010856	molecular_function	adenylate cyclase activator activity
AP	0016020	cellular_component	membrane
AP	0019001	molecular_function	guanyl nucleotide binding
AP	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
AP	0031748	molecular_function	D1 dopamine receptor binding
AP	0032588	cellular_component	trans-Golgi network membrane
AP	0046872	molecular_function	metal ion binding
AP	0046907	biological_process	intracellular transport
AP	0048589	biological_process	developmental growth
AP	0050796	biological_process	regulation of insulin secretion
AP	0050890	biological_process	cognition
AP	0060348	biological_process	bone development
AP	0060789	biological_process	hair follicle placode formation
AP	0070062	cellular_component	extracellular exosome
AP	0070527	biological_process	platelet aggregation
AP	0071377	biological_process	cellular response to glucagon stimulus
AP	0071380	biological_process	cellular response to prostaglandin E stimulus
AP	0071870	biological_process	cellular response to catecholamine stimulus
AP	0071880	biological_process	adenylate cyclase-activating adrenergic receptor signaling pathway
AP	0120162	biological_process	positive regulation of cold-induced thermogenesis
BP	0001750	cellular_component	photoreceptor outer segment
BP	0003924	molecular_function	GTPase activity
BP	0005515	molecular_function	protein binding
BP	0005737	cellular_component	cytoplasm
BP	0005765	cellular_component	lysosomal membrane
BP	0005829	cellular_component	cytosol
BP	0005834	cellular_component	heterotrimeric G-protein complex
BP	0005886	cellular_component	plasma membrane
BP	0007165	biological_process	signal transduction
BP	0007186	biological_process	G protein-coupled receptor signaling pathway
BP	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
BP	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
BP	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
BP	0007265	biological_process	Ras protein signal transduction
BP	0008283	biological_process	cell population proliferation
BP	0016020	cellular_component	membrane
BP	0030159	molecular_function	signaling receptor complex adaptor activity
BP	0044877	molecular_function	protein-containing complex binding
BP	0045202	cellular_component	synapse
BP	0050909	biological_process	sensory perception of taste
BP	0051020	molecular_function	GTPase binding
BP	0060041	biological_process	retina development in camera-type eye
BP	0070062	cellular_component	extracellular exosome
BP	0071380	biological_process	cellular response to prostaglandin E stimulus
BP	0071870	biological_process	cellular response to catecholamine stimulus
BP	0097381	cellular_component	photoreceptor disc membrane
BP	1903561	cellular_component	extracellular vesicle
GP	0005515	molecular_function	protein binding
GP	0005834	cellular_component	heterotrimeric G-protein complex
GP	0005886	cellular_component	plasma membrane
GP	0007165	biological_process	signal transduction
GP	0007186	biological_process	G protein-coupled receptor signaling pathway
GP	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
GP	0016020	cellular_component	membrane
GP	0031681	molecular_function	G-protein beta-subunit binding
GP	0048144	biological_process	fibroblast proliferation
GP	0070062	cellular_component	extracellular exosome
GP	0071380	biological_process	cellular response to prostaglandin E stimulus
GP	0071870	biological_process	cellular response to catecholamine stimulus
RP	0004888	molecular_function	transmembrane signaling receptor activity
RP	0004930	molecular_function	G protein-coupled receptor activity
RP	0004967	molecular_function	glucagon receptor activity
RP	0005515	molecular_function	protein binding
RP	0005886	cellular_component	plasma membrane
RP	0007166	biological_process	cell surface receptor signaling pathway
RP	0007186	biological_process	G protein-coupled receptor signaling pathway
RP	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
RP	0007190	biological_process	activation of adenylate cyclase activity
RP	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
RP	0007611	biological_process	learning or memory
RP	0008016	biological_process	regulation of heart contraction
RP	0008528	molecular_function	G protein-coupled peptide receptor activity
RP	0016020	cellular_component	membrane
RP	0017046	molecular_function	peptide hormone binding
RP	0019933	biological_process	cAMP-mediated signaling
RP	0031204	biological_process	post-translational protein targeting to membrane, translocation
RP	0038023	molecular_function	signaling receptor activity
RP	0044508	molecular_function	glucagon-like peptide 1 receptor activity
RP	0045776	biological_process	negative regulation of blood pressure
RP	0045777	biological_process	positive regulation of blood pressure
RP	0046879	biological_process	hormone secretion
RP	0071377	biological_process	cellular response to glucagon stimulus
RP	1990911	biological_process	response to psychosocial stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue N2V RP 501

Chain	Residue
RP	TYR145
RP	TYR220
RP	PHE230
RP	TRP297
RP	TYR148
RP	VAL194
RP	LYS197
RP	ALA200
RP	LEU201
RP	TRP203
RP	MET204
RP	LEU217

Functional Information from PROSITE/UniProt

site_id	PS00649
Number of Residues	25
Details	G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDeya.CWpdGepgsfvnvsCP

Chain	Residue	Details
RP	CYS62-PRO86

site_id	PS00650
Number of Residues	16
Details	G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLMVaILYCFvNneV

Chain	Residue	Details
RP	GLN394-VAL409

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
BP	LEU70-SER84
BP	ILE157-ILE171
BP	LEU285-ALA299

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	166
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:28514449

Chain	Residue	Details
RP	ARG24-GLU139
RP	LYS202-ARG227
RP	TYR291-TYR305
RP	MET371-LYS383
AP	ASP223
AP	ASN292
AP	ALA366

site_id	SWS_FT_FI2
Number of Residues	24
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:28514449

Chain	Residue	Details
RP	GLN140-ALA164

site_id	SWS_FT_FI3
Number of Residues	100
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:28514449

Chain	Residue	Details
RP	ILE165-THR175
RP	TYR252-ILE265
RP	CYS329-ARG348
RP	VAL405-SER463

site_id	SWS_FT_FI4
Number of Residues	25
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:28514449

Chain	Residue	Details
RP	ARG176-LEU201

site_id	SWS_FT_FI5
Number of Residues	23
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:28514449

Chain	Residue	Details
RP	LEU228-LEU251

site_id	SWS_FT_FI6
Number of Residues	24
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:28514449

Chain	Residue	Details
RP	PHE266-LEU290

site_id	SWS_FT_FI7
Number of Residues	22
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:28514449

Chain	Residue	Details
RP	TRP306-ILE328

site_id	SWS_FT_FI8
Number of Residues	21
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:28514449

Chain	Residue	Details
RP	LEU349-VAL370

site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:28514449

Chain	Residue	Details
RP	LEU384-PHE404

site_id	SWS_FT_FI10
Number of Residues	2
Details	SITE: Interaction with the endogenous ligand GLP-1 => ECO:0000269\|PubMed:19861722

Chain	Residue	Details
RP	ARG121
RP	GLU128

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: ADP-ribosylcysteine => ECO:0000269\|PubMed:21901419

Chain	Residue	Details
RP	CYS341

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: ADP-ribosylarginine => ECO:0000269\|PubMed:21901419

Chain	Residue	Details
RP	ARG348

site_id	SWS_FT_FI13
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:22412906

Chain	Residue	Details
RP	ASN63
RP	ASN82
RP	ASN115

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)