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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6ORV

Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AP0000166molecular_functionnucleotide binding
AP0001678biological_processintracellular glucose homeostasis
AP0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
AP0003091biological_processrenal water homeostasis
AP0003924molecular_functionGTPase activity
AP0003925molecular_functionG protein activity
AP0005515molecular_functionprotein binding
AP0005525molecular_functionGTP binding
AP0005737cellular_componentcytoplasm
AP0005829cellular_componentcytosol
AP0005834cellular_componentheterotrimeric G-protein complex
AP0005886cellular_componentplasma membrane
AP0007165biological_processsignal transduction
AP0007186biological_processG protein-coupled receptor signaling pathway
AP0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
AP0007190biological_processactivation of adenylate cyclase activity
AP0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
AP0007192biological_processadenylate cyclase-activating serotonin receptor signaling pathway
AP0007608biological_processsensory perception of smell
AP0010856molecular_functionadenylate cyclase activator activity
AP0014819biological_processregulation of skeletal muscle contraction
AP0016020cellular_componentmembrane
AP0016787molecular_functionhydrolase activity
AP0019001molecular_functionguanyl nucleotide binding
AP0031683molecular_functionG-protein beta/gamma-subunit complex binding
AP0031748molecular_functionD1 dopamine receptor binding
AP0032024biological_processpositive regulation of insulin secretion
AP0032588cellular_componenttrans-Golgi network membrane
AP0034695biological_processresponse to prostaglandin E
AP0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
AP0038184biological_processadenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway
AP0046872molecular_functionmetal ion binding
AP0046907biological_processintracellular transport
AP0048589biological_processdevelopmental growth
AP0050890biological_processcognition
AP0060348biological_processbone development
AP0060789biological_processhair follicle placode formation
AP0070062cellular_componentextracellular exosome
AP0070527biological_processplatelet aggregation
AP0071377biological_processcellular response to glucagon stimulus
AP0071380biological_processcellular response to prostaglandin E stimulus
AP0071468biological_processcellular response to acidic pH
AP0071870biological_processcellular response to catecholamine stimulus
AP0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
AP0097700biological_processvascular endothelial cell response to laminar fluid shear stress
AP0120162biological_processpositive regulation of cold-induced thermogenesis
BP0001750cellular_componentphotoreceptor outer segment
BP0003924molecular_functionGTPase activity
BP0005515molecular_functionprotein binding
BP0005737cellular_componentcytoplasm
BP0005765cellular_componentlysosomal membrane
BP0005829cellular_componentcytosol
BP0005834cellular_componentheterotrimeric G-protein complex
BP0005886cellular_componentplasma membrane
BP0007165biological_processsignal transduction
BP0007186biological_processG protein-coupled receptor signaling pathway
BP0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
BP0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
BP0007265biological_processRas protein signal transduction
BP0016020cellular_componentmembrane
BP0030159molecular_functionsignaling receptor complex adaptor activity
BP0044877molecular_functionprotein-containing complex binding
BP0045202cellular_componentsynapse
BP0051020molecular_functionGTPase binding
BP0070062cellular_componentextracellular exosome
BP0071380biological_processcellular response to prostaglandin E stimulus
BP0071870biological_processcellular response to catecholamine stimulus
BP0097381cellular_componentphotoreceptor disc membrane
BP1903561cellular_componentextracellular vesicle
GP0005515molecular_functionprotein binding
GP0005834cellular_componentheterotrimeric G-protein complex
GP0005886cellular_componentplasma membrane
GP0007165biological_processsignal transduction
GP0007186biological_processG protein-coupled receptor signaling pathway
GP0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
GP0016020cellular_componentmembrane
GP0031681molecular_functionG-protein beta-subunit binding
GP0045202cellular_componentsynapse
GP0070062cellular_componentextracellular exosome
GP0071380biological_processcellular response to prostaglandin E stimulus
GP0071870biological_processcellular response to catecholamine stimulus
RP0004888molecular_functiontransmembrane signaling receptor activity
RP0004930molecular_functionG protein-coupled receptor activity
RP0004967molecular_functionglucagon receptor activity
RP0005515molecular_functionprotein binding
RP0005886cellular_componentplasma membrane
RP0007165biological_processsignal transduction
RP0007166biological_processcell surface receptor signaling pathway
RP0007186biological_processG protein-coupled receptor signaling pathway
RP0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
RP0007190biological_processactivation of adenylate cyclase activity
RP0007204biological_processpositive regulation of cytosolic calcium ion concentration
RP0007611biological_processlearning or memory
RP0008016biological_processregulation of heart contraction
RP0008528molecular_functionG protein-coupled peptide receptor activity
RP0016020cellular_componentmembrane
RP0017046molecular_functionpeptide hormone binding
RP0038023molecular_functionsignaling receptor activity
RP0044508molecular_functionglucagon-like peptide 1 receptor activity
RP0045777biological_processpositive regulation of blood pressure
RP0071377biological_processcellular response to glucagon stimulus
RP1990911biological_processresponse to psychosocial stress
Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residue N2V RP 501
ChainResidue
RPTYR145
RPTYR220
RPPHE230
RPTRP297
RPTYR148
RPVAL194
RPLYS197
RPALA200
RPLEU201
RPTRP203
RPMET204
RPLEU217
Functional Information from PROSITE/UniProt
site_idPS00649
Number of Residues25
DetailsG_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDeya.CWpdGepgsfvnvsCP
ChainResidueDetails
RPCYS62-PRO86
site_idPS00650
Number of Residues16
DetailsG_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLMVaILYCFvNneV
ChainResidueDetails
RPGLN394-VAL409
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BPLEU70-SER84
BPILE157-ILE171
BPLEU285-ALA299
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues7
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P04896","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues48
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues45
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues40
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues41
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues43
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues41
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues30
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues23
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues51
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues3
DetailsRegion: {"description":"Important for allosteric inhibitor binding","evidences":[{"source":"PubMed","id":"28514449","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsModified residue: {"description":"ADP-ribosylarginine","evidences":[{"source":"PubMed","id":"21901419","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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