8JGG

CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22

Summary for 8JGG

• Entry DOI: 10.2210/pdb8jgg/pdb
• EMDB information: 36233
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, BAM8-22, Single-Chain Fragment Variable 16, ... (6 entities in total)
• Functional Keywords: itch receptor, mas-related gpcrs, mrgprx1, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 153853.55

Authors

Sun, J.P.,Xu, H.E.,Ynag, F.,Liu, Z.M.,Guo, L.L.,Zhang, Y.M.,Fang, G.X.,Tie, L.,Zhuang, Y.M.,Xue, C.Y. (deposition date: 2023-05-20, release date: 2024-01-10)

• Primary citation: Guo, L.,Zhang, Y.,Fang, G.,Tie, L.,Zhuang, Y.,Xue, C.,Liu, Q.,Zhang, M.,Zhu, K.,You, C.,Xu, P.,Yuan, Q.,Zhang, C.,Liu, L.,Rong, N.,Peng, S.,Liu, Y.,Wang, C.,Luo, X.,Lv, Z.,Kang, D.,Yu, X.,Zhang, C.,Jiang, Y.,Dong, X.,Zhou, J.,Liu, Z.,Yang, F.,Eric Xu, H.,Sun, J.P.; Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.; Nat Commun, 14:5004-5004, 2023; PubMed: 37591889; DOI: 10.1038/s41467-023-40705-z

Experimental method

ELECTRON MICROSCOPY (3 Å)