8JGG
CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 60 | 6633.6 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 2 | B (L) | BAM8-22 | polymer | 11 | 1603.8 | 1 | UniProt (P01210) | Homo sapiens | Met-enkephalin,Opioid growth factor,OGF |
| 3 | C (S) | Single-Chain Fragment Variable 16 | polymer | 285 | 30363.0 | 1 | Homo sapiens | ||
| 4 | D (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 5 | E (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 352 | 38561.2 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 6 | F (R) | Mas-related G-protein coupled receptor member X1 | polymer | 322 | 36276.9 | 1 | UniProt (Q96LB2) Pfam (PF00001) | Homo sapiens (human) | Sensory neuron-specific G-protein coupled receptor 3/4 |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Leu -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Val -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Phe -7 | - | expression tag |
| Gln -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Cys -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 153853.6 | |
| All* | Total formula weight | 153853.6 |
