8H2G

Cryo-EM structure of niacin bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer

Summary for 8H2G

• Entry DOI: 10.2210/pdb8h2g/pdb
• EMDB information: 34437
• Descriptor: Hydroxy-carboxylic acid receptor 2, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: gpcr, hydroxycarboxylic acid, g-protein, membrane protein, niacin, signaling
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 168502.94

Authors

Park, J.H.,Ishimoto, N.,Park, S.Y. (deposition date: 2022-10-06, release date: 2023-10-11, Last modification date: 2024-10-23)

• Primary citation: Park, J.H.,Kawakami, K.,Ishimoto, N.,Ikuta, T.,Ohki, M.,Ekimoto, T.,Ikeguchi, M.,Lee, D.S.,Lee, Y.H.,Tame, J.R.H.,Inoue, A.,Park, S.Y.; Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2; Nat Commun, 14:7150-, 2023; DOI: 10.1038/s41467-023-42764-8

Experimental method

ELECTRON MICROSCOPY (3.01 Å)