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6ZPN
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BU of 6zpn by Molmil
Crystal structure of Chaetomium thermophilum Raptor
Descriptor: WD_REPEATS_REGION domain-containing protein
Authors:Imseng, S, Boehm, R, Jakob, R.P, Hall, M.N, Hiller, S, Maier, T.
Deposit date:2020-07-08
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1.
Mol.Cell, 81, 2021
3MJW
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BU of 3mjw by Molmil
PI3 Kinase gamma with a benzofuranone inhibitor
Descriptor: (2Z)-4,6-dihydroxy-2-[(8-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)methylidene]-1-benzofuran-3(2H)-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:Bard, J, Svenson, K.
Deposit date:2010-04-13
Release date:2010-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:5-Ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-alpha and mTOR for the treatment of breast cancer.
Bioorg.Med.Chem.Lett., 20, 2010
4F1S
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BU of 4f1s by Molmil
Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine-sulfonamide inhibitor
Descriptor: N-(5-{[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl]amino}-2-chloropyridin-3-yl)methanesulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
Authors:Whittington, D.A, Tang, J, Yakowec, P.
Deposit date:2012-05-07
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.
Bioorg.Med.Chem.Lett., 22, 2012
3QJZ
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BU of 3qjz by Molmil
Crystal structure of PI3K-gamma in complex with benzothiazole 1
Descriptor: N-{6-[2-(methylsulfanyl)pyrimidin-4-yl]-1,3-benzothiazol-2-yl}acetamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
Authors:Whittington, D.A, Tang, J, Yakowec, P.
Deposit date:2011-01-31
Release date:2011-03-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors.
J.Med.Chem., 54, 2011
3QK0
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BU of 3qk0 by Molmil
Crystal structure of PI3K-gamma in complex with benzothiazole 82
Descriptor: N-[6-(6-chloro-5-{[(4-fluorophenyl)sulfonyl]amino}pyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
Authors:Whittington, D.A, Tang, J, Yakowec, P.
Deposit date:2011-01-31
Release date:2011-03-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors.
J.Med.Chem., 54, 2011
5DJ4
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BU of 5dj4 by Molmil
Leucine-bound Sestrin2 from Homo sapiens
Descriptor: LEUCINE, Sestrin-2
Authors:Saxton, R.A, Knockenhauer, K.E, Schwartz, T.U.
Deposit date:2015-09-01
Release date:2015-11-25
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.697 Å)
Cite:Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.
Science, 351, 2016
5I2C
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BU of 5i2c by Molmil
Arginine-bound CASTOR1 from Homo sapiens
Descriptor: ACETATE ION, ARGININE, GATS-like protein 3
Authors:Saxton, R.A, Knockenhauer, K.E, Schwartz, T.U.
Deposit date:2016-02-08
Release date:2016-08-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.
Nature, 536, 2016
6N0M
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BU of 6n0m by Molmil
CRYSTAL STRUCTURE OF SESTRIN2 IN COMPLEX WITH NV-0005138
Descriptor: 4-(difluoromethyl)-L-leucine, Sestrin-2
Authors:O'Neill, D.
Deposit date:2018-11-07
Release date:2019-04-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Discovery of NV-5138, the first selective Brain mTORC1 activator.
Sci Rep, 9, 2019
5GV2
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BU of 5gv2 by Molmil
Crystal structure of Arginine-bound CASTOR1 from Homo sapiens
Descriptor: ARGININE, GATS-like protein 3, MAGNESIUM ION
Authors:Gai, Z.C, Wu, G.
Deposit date:2016-09-01
Release date:2017-09-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway
Cell Discov, 2, 2016
3SEA
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BU of 3sea by Molmil
Structure of Rheb-Y35A mutant in GDP- and GMPPNP-bound forms
Descriptor: ACETATE ION, GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Mazhab-Jafari, M.T, Marshall, C.B, Ishiyama, N, Vuk, S, Ikura, M.
Deposit date:2011-06-10
Release date:2012-06-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:An Autoinhibited Noncanonical Mechanism of GTP Hydrolysis by Rheb Maintains mTORC1 Homeostasis.
Structure, 20, 2012
6S6D
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BU of 6s6d by Molmil
Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L.
Deposit date:2019-07-02
Release date:2019-10-16
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
6S6A
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BU of 6s6a by Molmil
Crystal structure of RagA-Q66L/RagC-T90N GTPase heterodimer complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L.
Deposit date:2019-07-02
Release date:2019-10-16
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
5YXH
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BU of 5yxh by Molmil
Structure of Rheb-GDP
Descriptor: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Mahoney, S.J.
Deposit date:2017-12-05
Release date:2018-02-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.
Nat Commun, 9, 2018
6BT0
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BU of 6bt0 by Molmil
CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND NR1
Descriptor: 4-bromo-6-[(3,4-dichlorophenyl)sulfanyl]-1-{[4-(dimethylcarbamoyl)phenyl]methyl}-1H-indole-2-carboxylic acid, GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Mahoney, S.J.
Deposit date:2017-12-04
Release date:2018-02-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.
Nat Commun, 9, 2018
6BSX
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BU of 6bsx by Molmil
CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND 1 AT 1.65A RESOLUTION
Descriptor: (5,6-dimethyl-1H-benzimidazol-2-yl)methanol, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Mahoney, S.J.
Deposit date:2017-12-04
Release date:2018-02-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.
Nat Commun, 9, 2018
5GS9
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BU of 5gs9 by Molmil
Crystal structure of CASTOR1-arginine
Descriptor: ARGININE, GATS-like protein 3
Authors:Zhang, T, Ding, J.
Deposit date:2016-08-15
Release date:2016-09-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling.
Cell Discov, 2, 2016
7A0N
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BU of 7a0n by Molmil
Structure of TSC1 NTD and linker domain
Descriptor: Uncharacterized protein,Uncharacterized protein
Authors:Fitzian, K, Kuemmel, D.
Deposit date:2020-08-10
Release date:2021-05-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Mol.Cell, 81, 2021
7A0M
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BU of 7a0m by Molmil
TSC1 N-terminal domain
Descriptor: SULFATE ION, TSC1 N-terminal domain
Authors:Zech, R, Kiontke, S, Kuemmel, D.
Deposit date:2020-08-10
Release date:2021-05-26
Last modified:2021-07-14
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Mol.Cell, 81, 2021
7LC2
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BU of 7lc2 by Molmil
Crystal Structure of KRAS4b-Q61R (GMPPNP-bound) in complex with the RAS-binding domain (RBD) of SIN1
Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Dharmaiah, S, Simanshu, D.K.
Deposit date:2021-01-09
Release date:2021-07-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
Proc.Natl.Acad.Sci.USA, 118, 2021
7LC1
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BU of 7lc1 by Molmil
Crystal Structure of KRAS4b (GMPPNP-bound) in complex with the RBD-PH domains of SIN1
Descriptor: Isoform 2B of GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Dharmaiah, S, Simanshu, D.K.
Deposit date:2021-01-09
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
Proc.Natl.Acad.Sci.USA, 118, 2021
6KIE
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BU of 6kie by Molmil
Crystal structure of human leucyl-tRNA synthetase, Leu-AMS-bound form
Descriptor: 5'-O-(L-leucylsulfamoyl)adenosine, LEUCINE, Leucine--tRNA ligase, ...
Authors:Kim, S, Son, J, Kim, S, Hwang, K.Y.
Deposit date:2019-07-18
Release date:2021-01-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
Cell Rep, 35, 2021
6KID
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BU of 6kid by Molmil
Crystal structure of human leucyl-tRNA synthetase, ATP-bound form
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, LEUCINE, Leucine--tRNA ligase, ...
Authors:Kim, S, Son, J, Kim, S, Hwang, K.Y.
Deposit date:2019-07-18
Release date:2021-01-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
Cell Rep, 35, 2021
6KQY
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BU of 6kqy by Molmil
Crystal structure of human leucyl-tRNA synthetase, Leucine-bound form
Descriptor: LEUCINE, Leucine--tRNA ligase, cytoplasmic, ...
Authors:Kim, S, Son, J, Kim, S, Hwang, K.Y.
Deposit date:2019-08-20
Release date:2021-01-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
Cell Rep, 35, 2021
6KR7
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BU of 6kr7 by Molmil
Crystal structure of methylated human leucyl-tRNA synthetase, Leu-AMS-bound form
Descriptor: 5'-O-(L-leucylsulfamoyl)adenosine, LEUCINE, Leucine--tRNA ligase, ...
Authors:Kim, S, Son, J, Kim, S, Hwang, K.Y.
Deposit date:2019-08-21
Release date:2021-01-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (4 Å)
Cite:Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
Cell Rep, 35, 2021
6ULG
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BU of 6ulg by Molmil
Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex
Descriptor: Folliculin, Folliculin-interacting protein 2, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Shen, K, Rogala, K.B, Yu, Z.H, Sabatini, D.M.
Deposit date:2019-10-08
Release date:2019-11-20
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.
Cell, 179, 2019

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