7LC1

Crystal Structure of KRAS4b (GMPPNP-bound) in complex with the RBD-PH domains of SIN1

Summary for 7LC1

• Entry DOI: 10.2210/pdb7lc1/pdb
• Descriptor: Isoform 2B of GTPase KRas, Target of rapamycin complex 2 subunit MAPKAP1, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: kras, ras, k-ras, oncoprotein, gmppnp, gppnhp, sin1, mapkap1, ph domain, rbd, ras-binding domain, effector, small gtpase, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 93563.61

Authors

Dharmaiah, S.,Simanshu, D.K. (deposition date: 2021-01-09, release date: 2021-08-04, Last modification date: 2023-10-18)

• Primary citation: Castel, P.,Dharmaiah, S.,Sale, M.J.,Messing, S.,Rizzuto, G.,Cuevas-Navarro, A.,Cheng, A.,Trnka, M.J.,Urisman, A.,Esposito, D.,Simanshu, D.K.,McCormick, F.; RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34380736; DOI: 10.1073/pnas.2103261118

Experimental method

X-RAY DIFFRACTION (2.35 Å)