4F1S
Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine-sulfonamide inhibitor
Summary for 4F1S
Entry DOI | 10.2210/pdb4f1s/pdb |
Related | 4DK5 |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-(5-{[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl]amino}-2-chloropyridin-3-yl)methanesulfonamide, ... (4 entities in total) |
Functional Keywords | phosphotransferase, lipid kinase, p85, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P48736 |
Total number of polymer chains | 1 |
Total formula weight | 110891.40 |
Authors | Whittington, D.A.,Tang, J.,Yakowec, P. (deposition date: 2012-05-07, release date: 2012-08-08, Last modification date: 2024-02-28) |
Primary citation | Wurz, R.P.,Liu, L.,Yang, K.,Nishimura, N.,Bo, Y.,Pettus, L.H.,Caenepeel, S.,Freeman, D.J.,McCarter, J.D.,Mullady, E.L.,Miguel, T.S.,Wang, L.,Zhang, N.,Andrews, K.L.,Whittington, D.A.,Jiang, J.,Subramanian, R.,Hughes, P.E.,Norman, M.H. Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold. Bioorg.Med.Chem.Lett., 22:5714-5720, 2012 Cited by PubMed: 22832322DOI: 10.1016/j.bmcl.2012.06.078 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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