3MJW
PI3 Kinase gamma with a benzofuranone inhibitor
Summary for 3MJW
Entry DOI | 10.2210/pdb3mjw/pdb |
Descriptor | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, (2Z)-4,6-dihydroxy-2-[(8-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)methylidene]-1-benzofuran-3(2H)-one (2 entities in total) |
Functional Keywords | atp-binding, kinase, nucleotide-binding, transferase |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 111134.54 |
Authors | Bard, J.,Svenson, K. (deposition date: 2010-04-13, release date: 2010-06-09, Last modification date: 2023-09-06) |
Primary citation | Zhang, N.,Ayral-Kaloustian, S.,Anderson, J.T.,Nguyen, T.,Das, S.,Venkatesan, A.M.,Brooijmans, N.,Lucas, J.,Yu, K.,Hollander, I.,Mallon, R. 5-Ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-alpha and mTOR for the treatment of breast cancer. Bioorg.Med.Chem.Lett., 20:3526-3529, 2010 Cited by PubMed: 20483602DOI: 10.1016/j.bmcl.2010.04.139 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
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