3MJW
PI3 Kinase gamma with a benzofuranone inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | polymer | 966 | 110756.2 | 1 | UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens | PtdIns-3-kinase subunit gamma, PI3-kinase subunit gamma, PI3K-gamma, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, PtdIns-3-kinase subunit p110-gamma, p120-PI3K |
2 | A | (2Z)-4,6-dihydroxy-2-[(8-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)methylidene]-1-benzofuran-3(2H)-one | non-polymer | 378.4 | 1 | Chemie (WYF) |
Sequence modifications
A: 144 - 1102 (UniProt: P48736)
PDB | External Database | Details |
---|---|---|
Met 143 | - | expression tag |
Arg 459 | Gln 459 | conflict |
His 1103 | - | expression tag |
His 1104 | - | expression tag |
His 1105 | - | expression tag |
His 1106 | - | expression tag |
His 1107 | - | expression tag |
His 1108 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 110756.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 378.4 | |
All* | Total formula weight | 111134.5 |