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3SEA

Structure of Rheb-Y35A mutant in GDP- and GMPPNP-bound forms

Summary for 3SEA
Entry DOI10.2210/pdb3sea/pdb
Related1XTQ 1XTR 1XTS 2L0X 3OES
DescriptorGTP-binding protein Rheb, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywordsglobular, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Lipid-anchor; Cytoplasmic side (Potential): Q15382
Total number of polymer chains2
Total formula weight38587.86
Authors
Mazhab-Jafari, M.T.,Marshall, C.B.,Ishiyama, N.,Vuk, S.,Ikura, M. (deposition date: 2011-06-10, release date: 2012-06-20, Last modification date: 2023-09-13)
Primary citationMazhab-Jafari, M.T.,Marshall, C.B.,Ishiyama, N.,Ho, J.,Di Palma, V.,Stambolic, V.,Ikura, M.
An Autoinhibited Noncanonical Mechanism of GTP Hydrolysis by Rheb Maintains mTORC1 Homeostasis.
Structure, 20:1528-1539, 2012
Cited by
PubMed: 22819219
DOI: 10.1016/j.str.2012.06.013
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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