6BT0

CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND NR1

Summary for 6BT0

Entry DOI	10.2210/pdb6bt0/pdb
Related	6BSX
Descriptor	GTP-binding protein Rheb, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	mtorc1 g-protein, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	83392.51
Authors	Mahoney, S.J. (deposition date: 2017-12-04, release date: 2018-02-28, Last modification date: 2023-10-04)
Primary citation	Mahoney, S.J.,Narayan, S.,Molz, L.,Berstler, L.A.,Kang, S.A.,Vlasuk, G.P.,Saiah, E. A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nat Commun, 9:548-548, 2018 Cited by PubMed: 29416044 DOI: 10.1038/s41467-018-03035-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation