6BT0

CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND NR1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	GTP-binding protein Rheb	polymer	178	20236.0	4	UniProt (Q15382) Pfam (PF00071) In PDB	Homo sapiens (Human)	Ras homolog enriched in brain
2	A, B, C, D	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
3	A, B, C, D	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	4	Chemie (GDP)
4	B	4-bromo-6-[(3,4-dichlorophenyl)sulfanyl]-1-{[4-(dimethylcarbamoyl)phenyl]methyl}-1H-indole-2-carboxylic acid	non-polymer		578.3	1	Chemie (E7V)
5		water	water		18.0	18	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 169 (UniProt: Q15382)

PDB	External Database	Details
Ser 0	-	expression tag
Leu 170	-	expression tag
Glu 171	-	expression tag
His 172	-	expression tag
His 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	80944.2
Non-Polymers*	Number of molecules	9
	Total formula weight	2448.3
All*	Total formula weight	83392.5

*Water molecules are not included.