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6BSX

CRYSTAL STRUCTURE OF RHEB IN COMPLEX WITH COMPOUND 1 AT 1.65A RESOLUTION

Summary for 6BSX
Entry DOI10.2210/pdb6bsx/pdb
Related1XTQ
DescriptorGTP-binding protein Rheb, MAGNESIUM ION, ACETATE ION, ... (7 entities in total)
Functional Keywordsmtorc1 g-protein, signaling protein
Biological sourceHomo sapiens (Human)
Cellular locationEndomembrane system ; Lipid-anchor ; Cytoplasmic side : Q15382
Total number of polymer chains4
Total formula weight84003.51
Authors
Mahoney, S.J. (deposition date: 2017-12-04, release date: 2018-02-28, Last modification date: 2023-10-04)
Primary citationMahoney, S.J.,Narayan, S.,Molz, L.,Berstler, L.A.,Kang, S.A.,Vlasuk, G.P.,Saiah, E.
A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.
Nat Commun, 9:548-548, 2018
Cited by
PubMed: 29416044
DOI: 10.1038/s41467-018-03035-z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.65 Å)
Structure validation

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