6N0M

CRYSTAL STRUCTURE OF SESTRIN2 IN COMPLEX WITH NV-0005138

Summary for 6N0M

Entry DOI	10.2210/pdb6n0m/pdb
Descriptor	Sestrin-2, 4-(difluoromethyl)-L-leucine (2 entities in total)
Functional Keywords	mtor, leucine, amino-acid, sensing, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	5
Total formula weight	238199.55
Authors	O'Neill, D. (deposition date: 2018-11-07, release date: 2019-04-10, Last modification date: 2023-10-11)
Primary citation	Sengupta, S.,Giaime, E.,Narayan, S.,Hahm, S.,Howell, J.,O'Neill, D.,Vlasuk, G.P.,Saiah, E. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep, 9:4107-4107, 2019 Cited by PubMed: 30858438 DOI: 10.1038/s41598-019-40693-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation