6N0M

CRYSTAL STRUCTURE OF SESTRIN2 IN COMPLEX WITH NV-0005138

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	1901031	biological_process	regulation of response to reactive oxygen species
B	0005634	cellular_component	nucleus
B	1901031	biological_process	regulation of response to reactive oxygen species
C	0005634	cellular_component	nucleus
C	1901031	biological_process	regulation of response to reactive oxygen species
D	0005634	cellular_component	nucleus
D	1901031	biological_process	regulation of response to reactive oxygen species
E	0005634	cellular_component	nucleus
E	1901031	biological_process	regulation of response to reactive oxygen species

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue K94 A 900

Chain	Residue
A	THR374
A	VAL455
A	TYR375
A	ASN376
A	THR377
A	THR386
A	LEU389
A	ARG390
A	TRP444
A	GLU451

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site_id	AC2
Number of Residues	10
Details	binding site for residue K94 B 900

Chain	Residue
B	THR374
B	TYR375
B	ASN376
B	THR377
B	THR386
B	ARG390
B	TRP444
B	GLU451
B	HIS454
B	VAL455

---

site_id	AC3
Number of Residues	11
Details	binding site for residue K94 C 900

Chain	Residue
C	THR374
C	TYR375
C	ASN376
C	THR377
C	THR386
C	ARG390
C	ILE393
C	TRP444
C	GLU451
C	HIS454
C	VAL455

---

site_id	AC4
Number of Residues	11
Details	binding site for residue K94 D 900

Chain	Residue
D	THR374
D	TYR375
D	ASN376
D	THR377
D	THR386
D	ARG390
D	ILE393
D	TRP444
D	GLU451
D	HIS454
D	VAL455

---

site_id	AC5
Number of Residues	12
Details	binding site for residue K94 E 900

Chain	Residue
E	THR374
E	TYR375
E	ASN376
E	THR377
E	THR386
E	LEU389
E	ARG390
E	ILE393
E	TRP444
E	GLU451
E	HIS454
E	VAL455

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305|PubMed:26612684

Chain	Residue	Details
A	CYS125
B	CYS125
C	CYS125
D	CYS125
E	CYS125

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site_id	SWS_FT_FI2
Number of Residues	15
Details	BINDING: BINDING => ECO:0000269|PubMed:26586190, ECO:0007744|PDB:5DJ4

Chain	Residue	Details
A	THR374
D	THR374
D	THR386
D	GLU451
E	THR374
E	THR386
E	GLU451
A	THR386
A	GLU451
B	THR374
B	THR386
B	GLU451
C	THR374
C	THR386
C	GLU451

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER249
B	SER249
C	SER249
D	SER249
E	SER249

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:35114100

Chain	Residue	Details
A	LYS175
B	LYS175
C	LYS175
D	LYS175
E	LYS175

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