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5YXH

Structure of Rheb-GDP

Summary for 5YXH
Entry DOI10.2210/pdb5yxh/pdb
DescriptorGTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsgtpase, mtorc1 signaling, rheb, signaling protein
Biological sourceHomo sapiens (Human)
Cellular locationEndomembrane system ; Lipid-anchor ; Cytoplasmic side : Q15382
Total number of polymer chains4
Total formula weight78973.89
Authors
Mahoney, S.J. (deposition date: 2017-12-05, release date: 2018-02-28, Last modification date: 2023-11-22)
Primary citationMahoney, S.J.,Narayan, S.,Molz, L.,Berstler, L.A.,Kang, S.A.,Vlasuk, G.P.,Saiah, E.
A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.
Nat Commun, 9:548-548, 2018
Cited by
PubMed: 29416044
DOI: 10.1038/s41467-018-03035-z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.04 Å)
Structure validation

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