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8TB0
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BU of 8tb0 by Molmil
Cryo-EM Structure of GPR61-G protein complex stabilized by scFv16
Descriptor: GPR61 fused to dominant negative G alpha S/I N18 chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Lees, J.A, Dias, J.M, Han, S.
Deposit date:2023-06-28
Release date:2023-10-04
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Nat Commun, 14, 2023
8T3V
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BU of 8t3v by Molmil
Cryo-EM structure of the DHA bound FFA1-Gq complex
Descriptor: CHOLESTEROL, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, ...
Authors:Zhang, X, Tikhonova, I, Milligan, G, Zhang, C.
Deposit date:2023-06-07
Release date:2024-01-24
Method:ELECTRON MICROSCOPY (3.39 Å)
Cite:Structural basis for the ligand recognition and signaling of free fatty acid receptors.
Sci Adv, 10, 2024
8T3S
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BU of 8t3s by Molmil
Cryo-EM structure of the Butyrate bound FFA2-Gq complex
Descriptor: CHOLESTEROL, Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhang, X, Tikhonova, I, Milligan, G, Zhang, C.
Deposit date:2023-06-07
Release date:2024-01-24
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Structural basis for the ligand recognition and signaling of free fatty acid receptors.
Sci Adv, 10, 2024
8T3Q
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BU of 8t3q by Molmil
Cryo-EM structure of the DHA bound FFA4-Gq complex
Descriptor: DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhang, X, Tikhonova, I, Milligan, G, Zhang, C.
Deposit date:2023-06-07
Release date:2024-01-24
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:Structural basis for the ligand recognition and signaling of free fatty acid receptors.
Sci Adv, 10, 2024
8T3O
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BU of 8t3o by Molmil
Cryo-EM structure of the TUG-891 bound FFA4-Gq complex
Descriptor: (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, ...
Authors:Zhang, X, Tikhonova, I, Milligan, G, Zhang, C.
Deposit date:2023-06-07
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Structural basis for the ligand recognition and signaling of free fatty acid receptors.
Sci Adv, 10, 2024
8SZI
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BU of 8szi by Molmil
Cryo-EM structure of PAM-free human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:He, F, Wu, C, Gao, Y, Skiniotis, G.
Deposit date:2023-05-29
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
8SZH
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BU of 8szh by Molmil
Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:He, F, Wu, C, Gao, Y, Skiniotis, G.
Deposit date:2023-05-29
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
8SZG
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BU of 8szg by Molmil
Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gq complex in lipid nanodiscs
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:He, F, Wu, C, Gao, Y, Skiniotis, G.
Deposit date:2023-05-29
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.
Nature, 626, 2024
8SOE
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BU of 8soe by Molmil
Phosphoinositide phosphate 3 kinase gamma bound with ADP and two Gbetagamma subunits in State 2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Chen, C.-L, Tesmer, J.J.G.
Deposit date:2023-04-28
Release date:2024-04-03
Last modified:2024-04-17
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma.
Nat.Struct.Mol.Biol., 2024
8SOD
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BU of 8sod by Molmil
Phosphoinositide phosphate 3 kinase gamma bound with ADP and two Gbetagamma subunits in State 1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Chen, C.-L, Tesmer, J.J.G.
Deposit date:2023-04-28
Release date:2024-04-03
Last modified:2024-04-17
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma.
Nat.Struct.Mol.Biol., 2024
8SOC
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BU of 8soc by Molmil
Phosphoinositide phosphate 3 kinase gamma bound with ADP and Gbetagamma
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Chen, C.-L, Tesmer, J.J.G.
Deposit date:2023-04-28
Release date:2024-04-03
Last modified:2024-04-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma.
Nat.Struct.Mol.Biol., 2024
8SMV
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BU of 8smv by Molmil
GPR161 Gs heterotrimer
Descriptor: CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Hoppe, N, Manglik, A, Harrison, S.
Deposit date:2023-04-26
Release date:2024-02-21
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Biorxiv, 2023
8SL3
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BU of 8sl3 by Molmil
Human adenylyl Cyclase 5 in complex with Gbg
Descriptor: Adenylate cyclase type 5, GERAN-8-YL GERAN, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Yen, Y.C, Tesmer, J.J.G.
Deposit date:2023-04-20
Release date:2024-04-03
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Structure of adenylyl cyclase 5 in complex with G beta gamma offers insights into ADCY5-related dyskinesia.
Nat.Struct.Mol.Biol., 2024
8SG1
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BU of 8sg1 by Molmil
Cryo-EM structure of CMKLR1 signaling complex
Descriptor: CHOLESTEROL, Chemerin 9, Chemerin-like receptor 1, ...
Authors:Zhang, X, Zhang, C.
Deposit date:2023-04-11
Release date:2023-11-01
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Structural basis of G protein-Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist.
Plos Biol., 21, 2023
8SAI
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BU of 8sai by Molmil
Cryo-EM structure of GPR34-Gi complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Yong, X.H, Zhao, C, Yan, W, Shao, Z.H.
Deposit date:2023-04-01
Release date:2023-10-04
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
Proc.Natl.Acad.Sci.USA, 120, 2023
8POK
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BU of 8pok by Molmil
Cryo-EM structure of cell-free synthesized human histamine H2 receptor coupled to heterotrimeric Gs protein in lipid environment
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HISTAMINE, ...
Authors:Schnelle, K, Koeck, Z, Persechino, M, Umbach, S, Schihada, H, Januliene, D, Parey, K, Pockes, S, Kolb, P, Doetsch, V, Moeller, A, Hilger, D, Bernhard, F.
Deposit date:2023-07-05
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G s complex in nanodisc environment.
Nat Commun, 15, 2024
8PM2
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BU of 8pm2 by Molmil
Structure of the murine trace amine-associated receptor TAAR7f bound to N,N-dimethylcyclohexylamine (DMCH) in complex with mini-Gs trimeric G protein
Descriptor: CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Gusach, A, Lee, Y, Edwards, P.C, Huang, F, Weyand, S.N, Tate, C.G.
Deposit date:2023-06-28
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Molecular recognition of an aversive odorant by the murine trace amine-associated receptor TAAR7f.
Biorxiv, 2023
8PKM
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BU of 8pkm by Molmil
Befiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex
Descriptor: (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, (3-chloranyl-4-fluoranyl-phenyl)-[4-fluoranyl-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone, 5-hydroxytryptamine receptor 1A, ...
Authors:Schneider, J, Gmeiner, P, Hove, T.T, Rasmussen, T, Boettcher, B.
Deposit date:2023-06-27
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Discovery of a functionally selective serotonin 1A receptor agonist for the treatment of pain
To Be Published
8PJK
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BU of 8pjk by Molmil
ST171-bound serotonin 5-HT1A receptor - Gi Protein Complex
Descriptor: (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 5-hydroxytryptamine receptor 1A, 6-[3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-4~{H}-1,4-benzoxazin-3-one, ...
Authors:Schneider, J, Gmeiner, P, Rasmussen, T, Boettcher, B.
Deposit date:2023-06-23
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Discovery of a functionally selective serotonin 1A receptor agonist for the treatment of pain
To Be Published
8KH5
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BU of 8kh5 by Molmil
Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Nie, Y, Qiu, Z, Zheng, S, Chen, S.
Deposit date:2023-08-21
Release date:2023-10-18
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.
Nat Commun, 14, 2023
8KH4
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BU of 8kh4 by Molmil
Cryo-EM structure of the GPR161-Gs complex
Descriptor: CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Nie, Y, Qiu, Z, Zheng, S, Chen, S.
Deposit date:2023-08-21
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.
Nat Commun, 14, 2023
8KGK
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BU of 8kgk by Molmil
Cryo-EM structure of the GPR61-Gs complex
Descriptor: G-protein coupled receptor 61, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Nie, Y, Qiu, Z, Zheng, S.
Deposit date:2023-08-19
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.
Nat Commun, 14, 2023
8KFZ
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BU of 8kfz by Molmil
Gi bound CCR8 in ligand free state
Descriptor: C-C chemokine receptor type 8,LgBiT fusion protein,Recombinant Human Rhinovirus, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Jiang, S, Lin, X, Wu, L.J, Xu, F.
Deposit date:2023-08-16
Release date:2024-02-07
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8.
Sci Adv, 10, 2024
8KFY
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BU of 8kfy by Molmil
Gi bound CCR8 complex with nonpeptide agonist ZK 756326
Descriptor: 2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol, C-C chemokine receptor type 8,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Jiang, S, Lin, X, Wu, L.J, Xu, F.
Deposit date:2023-08-16
Release date:2024-02-07
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8.
Sci Adv, 10, 2024
8KFX
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BU of 8kfx by Molmil
Gi bound CCR8 complex with nonpeptide agonist LMD-009
Descriptor: 8-[[3-(2-methoxyphenoxy)phenyl]methyl]-1-(2-phenylethyl)-1,3,8-triazaspiro[4.5]decan-4-one, C-C chemokine receptor type 8,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Jiang, S, Lin, X, Wu, L.J, Xu, F.
Deposit date:2023-08-16
Release date:2024-02-07
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8.
Sci Adv, 10, 2024

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數據於2024-06-12公開中

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