8POK

Cryo-EM structure of cell-free synthesized human histamine H2 receptor coupled to heterotrimeric Gs protein in lipid environment

Summary for 8POK

Entry DOI	10.2210/pdb8pok/pdb
EMDB information	17793
Descriptor	Histamine H2 receptor, Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
Functional Keywords	gpcr, cell-free, h2r, human histamine 2 receptor, active conformation, complex, detergent-free, lipid environment, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	146866.99
Authors	Schnelle, K.,Koeck, Z.,Persechino, M.,Umbach, S.,Schihada, H.,Januliene, D.,Parey, K.,Pockes, S.,Kolb, P.,Doetsch, V.,Moeller, A.,Hilger, D.,Bernhard, F. (deposition date: 2023-07-05, release date: 2024-03-06, Last modification date: 2024-03-13)
Primary citation	Kock, Z.,Schnelle, K.,Persechino, M.,Umbach, S.,Schihada, H.,Januliene, D.,Parey, K.,Pockes, S.,Kolb, P.,Dotsch, V.,Moller, A.,Hilger, D.,Bernhard, F. Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G s complex in nanodisc environment. Nat Commun, 15:1831-1831, 2024 Cited by PubMed: 38418462 DOI: 10.1038/s41467-024-46096-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation