8KH5
Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS
Summary for 8KH5
Entry DOI | 10.2210/pdb8kh5/pdb |
EMDB information | 37237 |
Descriptor | Probable G-protein coupled receptor 174, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total) |
Functional Keywords | gpcr, gs, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 134099.35 |
Authors | |
Primary citation | Nie, Y.,Qiu, Z.,Chen, S.,Chen, Z.,Song, X.,Ma, Y.,Huang, N.,Cyster, J.G.,Zheng, S. Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14:5901-5901, 2023 Cited by PubMed: 37737235DOI: 10.1038/s41467-023-41654-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.83 Å) |
Structure validation
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