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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8KH5

Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Probable G-protein coupled receptor 174polymer34039454.31UniProt (Q9BXC1)
Pfam (PF00001)		Homo sapiens (human)
2B
(B)		Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer24828907.71UniProt (P63092)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-stimulating G alpha protein
3C
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35739280.91UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)
4D
(E)		Nanobody 35polymer16017352.51Lama glama
5E
(D)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717845.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
6F, H
(A)		CHOLESTEROLnon-polymer386.72Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (176980071)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (23423981)
PubChem (44654663)
PubChem (46937002)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (59274407)
PubChem (45044259)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (5997)
PubChem (1551269)
PubChem (90070115)
PubChem (49853509)
PubChem (50990013)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (52934537)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (56621683)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (138967089)
PubChem (139566851)
PubChem (15939944)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (171828367)
PubChem (173516975)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (101624109)
PubChem (304)
PubChem (124225449)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (124429284)
PubChem (638019)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (1549081)
PubChem (1553803)
PubChem (5283629)
PubChem (5284644)
PubChem (5315842)
PubChem (6419195)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (130459183)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
7G
(A)		O-{HYDROXY[((2R)-2-HYDROXY-3-{[(1S)-1-HYDROXYPENTADECYL]OXY}PROPYL)OXY]PHOSPHORYL}-L-SERINEnon-polymer485.51Chemie (LPS)
PubChem (17754066)
PubChem (21158832)
PubChem (22316466)
PubChem (46936900)
PubChem (5288706)
Sequence modifications
A: 2 - 328 (UniProt: Q9BXC1)
PDBExternal DatabaseDetails
Asp -7-expression tag
Tyr -6-expression tag
Lys -5-expression tag
Asp -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Asp -1-expression tag
Lys 0-expression tag
Ala 1-expression tag
Glu 324Thr 324conflict
Leu 325Ala 325conflict
Glu 326Ser 326conflict
Val 327Thr 327conflict
Leu 328Met 328conflict
Phe 329-expression tag
Gln 330-expression tag
Gly 331-expression tag
Pro 332-expression tag
B: 6 - 195 (UniProt: P63092)
PDBExternal DatabaseDetails
Asp 49Gly 49engineered mutation
Asn 50Glu 50engineered mutation
B: 204 - 394 (UniProt: P63092)
PDBExternal DatabaseDetails
Gly 196-linker
Gly 197-linker
Ser 198-linker
Gly 199-linker
Gly 200-linker
Ser 201-linker
Gly 202-linker
Gly 203-linker
Asp 249Ala 249engineered mutation
Asp 252Ser 252engineered mutation
-Asn 254deletion
-Met 255deletion
-Val 256deletion
-Ile 257deletion
-Arg 258deletion
-Glu 259deletion
-Asp 260deletion
-Asn 261deletion
-Gln 262deletion
-Thr 263deletion
Ala 372Ile 372conflict
Ile 375Val 375conflict
C: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
Leu -10-expression tag
Glu -9-expression tag
Val -8-expression tag
Leu -7-expression tag
Phe -6-expression tag
Gln -5-expression tag
Gly -4-expression tag
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Arg 145Tyr 145engineered mutation
D: 1 - 71 (UniProt: P59768)
PDBExternal DatabaseDetails
Ser 68Cys 68engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight132840.5
Non-Polymers*Number of molecules3
Total formula weight1258.9
All*Total formula weight134099.4
*Water molecules are not included.

253795

PDB entries from 2026-05-20

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