8SAI

Cryo-EM structure of GPR34-Gi complex

Summary for 8SAI

Entry DOI	10.2210/pdb8sai/pdb
EMDB information	40270
Descriptor	Probable G-protein coupled receptor 34, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (6 entities in total)
Functional Keywords	complex, agonist, membrane protein, lipid binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	169895.03
Authors	Yong, X.H.,Zhao, C.,Yan, W.,Shao, Z.H. (deposition date: 2023-04-01, release date: 2023-10-04)
Primary citation	Xia, A.,Yong, X.,Zhang, C.,Lin, G.,Jia, G.,Zhao, C.,Wang, X.,Hao, Y.,Wang, Y.,Zhou, P.,Yang, X.,Deng, Y.,Wu, C.,Chen, Y.,Zhu, J.,Tang, X.,Liu, J.,Zhang, S.,Zhang, J.,Xu, Z.,Hu, Q.,Zhao, J.,Yue, Y.,Yan, W.,Su, Z.,Wei, Y.,Zhou, R.,Dong, H.,Shao, Z.,Yang, S. Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Proc.Natl.Acad.Sci.USA, 120:e2308435120-e2308435120, 2023 Cited by PubMed: 37733739 DOI: 10.1073/pnas.2308435120 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.27 Å)

Structure validation