8KH4

Cryo-EM structure of the GPR161-Gs complex

Summary for 8KH4

• Entry DOI: 10.2210/pdb8kh4/pdb
• EMDB information: 37236
• Descriptor: G-protein coupled receptor 161, Guanine nucleotide-binding protein G(olf) subunit alpha,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: gpcr, gs, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 135873.03

Authors

Nie, Y.,Qiu, Z.,Zheng, S.,Chen, S. (deposition date: 2023-08-21, release date: 2023-10-11)

• Primary citation: Nie, Y.,Qiu, Z.,Chen, S.,Chen, Z.,Song, X.,Ma, Y.,Huang, N.,Cyster, J.G.,Zheng, S.; Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.; Nat Commun, 14:5901-5901, 2023; PubMed: 37737235; DOI: 10.1038/s41467-023-41654-3

Experimental method

ELECTRON MICROSCOPY (3.1 Å)