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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8KH4

Cryo-EM structure of the GPR161-Gs complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		G-protein coupled receptor 161polymer37341999.11UniProt (Q8N6U8)
Pfam (PF00001)		Homo sapiens (human)
2B
(B)		Guanine nucleotide-binding protein G(olf) subunit alpha,Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer24929008.81UniProt (P38405)
UniProt (P63092)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-stimulating G alpha protein,olfactory type,Adenylate cyclase-stimulating G alpha protein
3C
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35739280.91UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)
4D
(E)		Nanobody 35polymer16017352.51Lama glama
5E
(D)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717845.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
6F
(A)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (45044259)
PubChem (23423981)
PubChem (49853509)
PubChem (50990013)
PubChem (52934537)
PubChem (56621683)
PubChem (191463)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (368063)
PubChem (369319)
PubChem (44654663)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (46937002)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (638019)
PubChem (59274407)
PubChem (1549081)
PubChem (1553803)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (89951918)
PubChem (90224410)
PubChem (5997)
PubChem (5283629)
PubChem (5284644)
PubChem (1551269)
PubChem (90070115)
PubChem (91298236)
PubChem (5315842)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (6419195)
PubChem (10861996)
PubChem (132837164)
PubChem (101624109)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (124225449)
PubChem (138967089)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (139566851)
PubChem (124429284)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (15939944)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (171828367)
PubChem (173516975)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
Sequence modifications
A: 2 - 348 (UniProt: Q8N6U8)
PDBExternal DatabaseDetails
Asp -7-expression tag
Tyr -6-expression tag
Lys -5-expression tag
Asp -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Asp -1-expression tag
Lys 0-expression tag
Ala 1-expression tag
Glu 349-expression tag
Leu 350-expression tag
Glu 351-expression tag
Val 352-expression tag
Leu 353-expression tag
Phe 354-expression tag
Gln 355-expression tag
Gly 356-expression tag
Pro 357-expression tag
Leu 358-expression tag
Glu 359-expression tag
Val 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Gln 363-expression tag
Gly 364-expression tag
Pro 365-expression tag
B: 5 - 195 (UniProt: P38405)
PDBExternal DatabaseDetails
Arg 13Gly 15engineered mutation
Asn 14Val 16engineered mutation
Glu 15Asp 17engineered mutation
Ala 18Glu 20engineered mutation
Gln 19Arg 21engineered mutation
Asp 33Glu 35engineered mutation
Lys 34Arg 36engineered mutation
Gln 35Leu 37engineered mutation
Val 36Ala 38engineered mutation
Arg 38Lys 40engineered mutation
Asp 49Gly 51engineered mutation
Asn 50Glu 52engineered mutation
Gly 196-linker
Gly 197-linker
Ser 198-linker
Gly 199-linker
Gly 200-linker
Ser 201-linker
Gly 202-linker
Gly 203-linker
B: 204 - 394 (UniProt: P63092)
PDBExternal DatabaseDetails
Asp 249Ala 249engineered mutation
Asp 252Ser 252engineered mutation
-Asn 254deletion
-Met 255deletion
-Val 256deletion
-Ile 257deletion
-Arg 258deletion
-Glu 259deletion
-Asp 260deletion
-Asn 261deletion
-Gln 262deletion
-Thr 263deletion
Ala 372Ile 372engineered mutation
Ile 375Val 375engineered mutation
C: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
Leu -10-expression tag
Glu -9-expression tag
Val -8-expression tag
Leu -7-expression tag
Phe -6-expression tag
Gln -5-expression tag
Gly -4-expression tag
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Arg 145Tyr 145conflict
D: 1 - 71 (UniProt: P59768)
PDBExternal DatabaseDetails
Ser 68Cys 68engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight135486.4
Non-Polymers*Number of molecules1
Total formula weight386.7
All*Total formula weight135873.0
*Water molecules are not included.

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PDB entries from 2026-05-13

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