8SOD

Phosphoinositide phosphate 3 kinase gamma bound with ADP and two Gbetagamma subunits in State 1

Summary for 8SOD

Entry DOI	10.2210/pdb8sod/pdb
Related	8SO9 8SOA 8SOB 8SOC 8SOE
EMDB information	40650 40651 40652 40653 40654 40655
Descriptor	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, phosphatidylinositol-4,5-bisphosphate 3-kinase, Phosphoinositide 3-kinase regulatory subunit 5, ... (5 entities in total)
Functional Keywords	phosphoinositide 3-kinase, chemotaxis, cancer, signaling protein
Biological source	Bos taurus (cattle) More
Total number of polymer chains	6
Total formula weight	318680.28
Authors	Chen, C.-L.,Tesmer, J.J.G. (deposition date: 2023-04-28, release date: 2024-04-03, Last modification date: 2024-04-17)
Primary citation	Chen, C.L.,Syahirah, R.,Ravala, S.K.,Yen, Y.C.,Klose, T.,Deng, Q.,Tesmer, J.J.G. Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 38565696 DOI: 10.1038/s41594-024-01265-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation