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8SOD

Phosphoinositide phosphate 3 kinase gamma bound with ADP and two Gbetagamma subunits in State 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0002376biological_processimmune system process
A0004674molecular_functionprotein serine/threonine kinase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005943cellular_componentphosphatidylinositol 3-kinase complex, class IA
A0005944cellular_componentphosphatidylinositol 3-kinase complex, class IB
A0006629biological_processlipid metabolic process
A0006897biological_processendocytosis
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0016303molecular_function1-phosphatidylinositol-3-kinase activity
A0035005molecular_function1-phosphatidylinositol-4-phosphate 3-kinase activity
A0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
A0046934molecular_function1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
A0048015biological_processphosphatidylinositol-mediated signaling
A0106310molecular_functionprotein serine kinase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0005942cellular_componentphosphatidylinositol 3-kinase complex
B0005944cellular_componentphosphatidylinositol 3-kinase complex, class IB
B0007186biological_processG protein-coupled receptor signaling pathway
B0016020cellular_componentmembrane
B0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0043406biological_processpositive regulation of MAP kinase activity
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0046935molecular_function1-phosphatidylinositol-3-kinase regulator activity
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005834cellular_componentheterotrimeric G-protein complex
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0030159molecular_functionsignaling receptor complex adaptor activity
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
C0097381cellular_componentphotoreceptor disc membrane
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0031681molecular_functionG-protein beta-subunit binding
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005834cellular_componentheterotrimeric G-protein complex
E0007165biological_processsignal transduction
E0007186biological_processG protein-coupled receptor signaling pathway
E0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
E0016020cellular_componentmembrane
E0030159molecular_functionsignaling receptor complex adaptor activity
E0071380biological_processcellular response to prostaglandin E stimulus
E0071870biological_processcellular response to catecholamine stimulus
E0097381cellular_componentphotoreceptor disc membrane
F0003924molecular_functionGTPase activity
F0005515molecular_functionprotein binding
F0005834cellular_componentheterotrimeric G-protein complex
F0005886cellular_componentplasma membrane
F0007165biological_processsignal transduction
F0007186biological_processG protein-coupled receptor signaling pathway
F0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
F0016020cellular_componentmembrane
F0031681molecular_functionG-protein beta-subunit binding
F0071380biological_processcellular response to prostaglandin E stimulus
F0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
ELEU70-SER84
EILE157-ILE171
ELEU285-ALA299

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ
ChainResidueDetails
APHE832-GLN846

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN
ChainResidueDetails
ASER931-ASN951

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:9094719
ChainResidueDetails
BMET1
ALEU864
APHE961

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8WYR1
ChainResidueDetails
BSER456
BSER505

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:P48736
ChainResidueDetails
ASER1101
DSER68

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PDB entries from 2024-07-24

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