8KFY

Gi bound CCR8 complex with nonpeptide agonist ZK 756326

Summary for 8KFY

• Entry DOI: 10.2210/pdb8kfy/pdb
• EMDB information: 37208
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, gi, agonist, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 185350.09

Authors

Jiang, S.,Lin, X.,Wu, L.J.,Xu, F. (deposition date: 2023-08-16, release date: 2024-02-07, Last modification date: 2024-02-14)

• Primary citation: Jiang, S.,Lin, X.,Wu, L.,Wang, L.,Wu, Y.,Xu, Z.,Xu, F.; Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8.; Sci Adv, 10:eadj7500-eadj7500, 2024; PubMed: 38306437; DOI: 10.1126/sciadv.adj7500

Experimental method

ELECTRON MICROSCOPY (3.06 Å)