8KFY
Gi bound CCR8 complex with nonpeptide agonist ZK 756326
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40472.1 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 366 | 39728.4 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (R) | C-C chemokine receptor type 8,Fusion protein | polymer | 575 | 65061.4 | 1 | UniProt (P51685) Pfam (PF00001) | Homo sapiens (human) | C-C CKR-8,CC-CKR-8,CCR-8,CC chemokine receptor CHEMR1,CMKBRL2,Chemokine receptor-like 1,CKR-L1,GPR-CY6,GPRCY6,TER1 |
| 5 | E (S) | scFv16 | polymer | 297 | 31870.6 | 1 | Homo sapiens (human) | ||
| 6 | F (R) | 2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol | non-polymer | 356.5 | 1 | Chemie (OXF) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 1 - 340 (UniProt: P62873)
R: 1 - 355 (UniProt: P51685)
R: 356 - 548 (PDB: 8KFY)
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | conflict |
| Ala 203 | Gly 203 | conflict |
| Ser 326 | Ala 326 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Val 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Gly 358 | - | expression tag |
| Trp 359 | - | expression tag |
| Arg 360 | - | expression tag |
| Leu 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Lys 364 | - | expression tag |
| Ile 365 | - | expression tag |
| Ser 366 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -26 | - | initiating methionine |
| Lys -25 | - | expression tag |
| Thr -24 | - | expression tag |
| Ile -23 | - | expression tag |
| Ile -22 | - | expression tag |
| Ala -21 | - | expression tag |
| Leu -20 | - | expression tag |
| Ser -19 | - | expression tag |
| Tyr -18 | - | expression tag |
| Ile -17 | - | expression tag |
| Phe -16 | - | expression tag |
| Cys -15 | - | expression tag |
| Leu -14 | - | expression tag |
| Val -13 | - | expression tag |
| Phe -12 | - | expression tag |
| Ala -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Tyr -9 | - | expression tag |
| Lys -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Arg -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 184993.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 356.5 | |
| All* | Total formula weight | 185350.1 |
