8SL3

Human adenylyl Cyclase 5 in complex with Gbg

Summary for 8SL3

Entry DOI	10.2210/pdb8sl3/pdb
EMDB information	40572
Descriptor	Adenylate cyclase type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (4 entities in total)
Functional Keywords	adenylyl cyclase, g-proteins, complex, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	184618.87
Authors	Yen, Y.C.,Tesmer, J.J.G. (deposition date: 2023-04-20, release date: 2024-04-03, Last modification date: 2024-04-24)
Primary citation	Yen, Y.C.,Li, Y.,Chen, C.L.,Klose, T.,Watts, V.J.,Dessauer, C.W.,Tesmer, J.J.G. Structure of adenylyl cyclase 5 in complex with G beta gamma offers insights into ADCY5-related dyskinesia. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 38589608 DOI: 10.1038/s41594-024-01263-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (7 Å)

Structure validation