8SZG

Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gq complex in lipid nanodiscs

Summary for 8SZG

• Entry DOI: 10.2210/pdb8szg/pdb
• EMDB information: 40915
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, SPERMINE, CALCIUM ION, ... (15 entities in total)
• Functional Keywords: family c gpcr, calcium-sensing receptor (casr), heterotrimeric g protein, cryo-em, lipid nanodiscs, positive allosteric modulator, membrane protein, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 326316.01

Authors

He, F.,Wu, C.,Gao, Y.,Skiniotis, G. (deposition date: 2023-05-29, release date: 2024-02-07, Last modification date: 2024-03-13)

• Primary citation: He, F.,Wu, C.G.,Gao, Y.,Rahman, S.N.,Zaoralova, M.,Papasergi-Scott, M.M.,Gu, T.J.,Robertson, M.J.,Seven, A.B.,Li, L.,Mathiesen, J.M.,Skiniotis, G.; Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor.; Nature, 626:1141-1148, 2024; PubMed: 38326620; DOI: 10.1038/s41586-024-07055-2

Experimental method

ELECTRON MICROSCOPY (3.6 Å)