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8H4R
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The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, G1/S-specific cyclin-E1, ...
著者Gui, W, Wang, F, Cheng, W, Gao, J, Huang, Y, Ouyang, Z.
登録日2022-10-11
公開日2023-10-11
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus
To Be Published
1W98
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The structural basis of CDK2 activation by cyclin E
分子名称: CELL DIVISION PROTEIN KINASE 2, G1/S-SPECIFIC CYCLIN E1
著者Lowe, E.D, Honda, R, Dubinina, E, Skamnaki, V, Cook, A, Johnson, L.N.
登録日2004-10-07
公開日2005-02-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The Structure of Cyclin E1/Cdk2: Implications for Cdk2 Activation and Cdk2-Independent Roles
Embo J., 24, 2005
8BZO
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Cryo-EM structure of CDK2-CyclinA in complex with p27 from the SCFSKP2 E3 ligase Complex
分子名称: Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B
著者Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E.
登録日2022-12-15
公開日2023-06-28
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1.
Sci Rep, 13, 2023
6ATH
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Cdk2/cyclin A/p27-KID-deltaC
分子名称: Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, ...
著者White, S.W, Yun, M.
登録日2017-08-29
公開日2018-09-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation.
Nat Commun, 10, 2019
7SJ3
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Structure of CDK4-Cyclin D3 bound to abemaciclib
分子名称: Cyclin-dependent kinase 4, G1/S-specific cyclin-D3, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine
著者Hilgers, M.T, Pelletier, L.A.
登録日2021-10-15
公開日2022-11-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structure of CDK4-Cyclin D3 bound to abemaciclib
To Be Published
7QHL
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Crystal structure of Cyclin-dependent kinase 2/cyclin A in complex with 3,5,7-Substituted pyrazolo[4,3-d]pyrimidine inhibitor 24
分子名称: 1,2-ETHANEDIOL, 5-(2-amino-1-ethyl)thio-3-cyclobutyl-7-[4-(pyrazol-1-yl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidine, Cyclin-A2, ...
著者Djukic, S, Skerlova, J, Rezacova, P.
登録日2021-12-13
公開日2022-07-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献3,5,7-Substituted Pyrazolo[4,3- d ]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
J.Med.Chem., 65, 2022
7XQK
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The Crystal Structure of CDK3 and CyclinE1 Complex from Biortus.
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, G1/S-specific cyclin-E1, GLYCEROL, ...
著者Gui, W, Wang, F, Cheng, W, Gao, J, Huang, Y.
登録日2022-05-07
公開日2023-05-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献The Crystal Structure of CDK3 and CyclinE1 Complex from Biortus.
To Be Published
5NEV
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CDK2/Cyclin A in complex with compound 73
分子名称: 4-[[6-(3-phenylphenyl)-7~{H}-purin-2-yl]amino]benzenesulfonamide, Cyclin-A2, Cyclin-dependent kinase 2
著者Coxon, C.R, Anscombe, E, Harnor, S.J, Martin, M.P, Carbain, B, Hardcastle, I.R, Harlow, L.K, Korolchuk, S, Matheson, C.J, Noble, M.E.M, Newell, D.R, Turner, D, Sivaprakasam, M, Wang, L.Z, Wong, C, Golding, B.T, Griffin, R.J, Cano, G.
登録日2017-03-12
公開日2017-03-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.
J. Med. Chem., 60, 2017
3MY5
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CDk2/cyclinA in complex with DRB
分子名称: 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole, Cell division protein kinase 2, Cyclin-A2, ...
著者Baumli, S, Johnson, L.N.
登録日2010-05-09
公開日2010-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Halogen bonds form the basis for selective P-TEFb inhibition by DRB
Chem.Biol., 17, 2010
8ROZ
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Cryo-EM structure of CDK2-cyclin A in complex with CDC25A
分子名称: Cyclin-A2, Cyclin-dependent kinase 2, M-phase inducer phosphatase 1
著者Rowland, R.J, Noble, M.E.M, Endicott, J.A.
登録日2024-01-12
公開日2024-05-29
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Cryo-EM structure of the CDK2-cyclin A-CDC25A Complex
To Be Published
5CYI
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CDK2/Cyclin A covalent complex with 6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine (NU6300)
分子名称: 6-(cyclohexylmethoxy)-N-[4-(ethylsulfonyl)phenyl]-9H-purin-2-amine, Cyclin-A2, Cyclin-dependent kinase 2
著者Anscombe, E, Meschini, E, Vidal, R.M, Martin, M.P, Staunton, D, Geitmann, M, Danielson, U.H, Stanley, W.A, Wang, L.Z, Reuillon, T, Golding, B.T, Cano, C, Newell, D.R, Noble, M.E.M, Wedge, S.R, Endicott, J.A, Griffin, R.J.
登録日2015-07-30
公開日2015-09-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Identification and Characterization of an Irreversible Inhibitor of CDK2.
Chem.Biol., 22, 2015
7KJS
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Crystal structure of CDK2/cyclin E in complex with PF-06873600
分子名称: 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1
著者McTigue, M.A, He, Y, Ferre, R.A.
登録日2020-10-26
公開日2021-06-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.187 Å)
主引用文献Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
J.Med.Chem., 64, 2021
1E9H
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Thr 160 phosphorylated CDK2 - Human cyclin A3 complex with the inhibitor indirubin-5-sulphonate bound
分子名称: 2',3-DIOXO-1,1',2',3-TETRAHYDRO-2,3'-BIINDOLE-5'-SULFONIC ACID, CELL DIVISION PROTEIN KINASE 2, CYCLIN A3
著者Davies, T.G, Tunnah, P, Noble, M.E.M, Endicott, J.A.
登録日2000-10-16
公開日2001-10-11
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Inhibitor Binding to Active and Inactive Cdk2: The Crystal Structure of Cdk2-Cyclin A/Indirubin-5-Sulphonate
Structure, 9, 2001
4Y72
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Human CDK1/CyclinB1/CKS2 With Inhibitor
分子名称: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ...
著者Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A.
登録日2015-02-13
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
8VQ4
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CDK2-CyclinE1 in complex with allosteric inhibitor I-125A.
分子名称: (8R)-6-(1-benzyl-1H-pyrazole-4-carbonyl)-N-[(2S,3R)-3-(2-cyclohexylethoxy)-1-(methylamino)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1
著者Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B.
登録日2024-01-17
公開日2024-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Expanding the ligandable proteome by paralog hopping with covalent probes.
Biorxiv, 2024
8VQ3
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CDK2-CyclinE1 in complex with allosteric inhibitor I-198.
分子名称: (8R)-N-[(2S,3R)-3-(cyclohexylmethoxy)-1-(morpholin-4-yl)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-6-(1,3-thiazole-5-carbonyl)-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1
著者Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B.
登録日2024-01-17
公開日2024-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Expanding the ligandable proteome by paralog hopping with covalent probes.
Biorxiv, 2024
4YC3
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CDK1/CyclinB1/CKS2 Apo
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, ...
著者Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A.
登録日2015-02-19
公開日2016-04-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
6RIJ
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CDK2/cyclin A2 in complex with open-ring 5-nitrosopyrimidine inhibitor LC436
分子名称: 4-[[[5-nitroso-2-[[(2~{R})-1-oxidanylbutan-2-yl]amino]-6-(propan-2-ylamino)pyrimidin-4-yl]amino]methyl]phenol, Cyclin-A2, Cyclin-dependent kinase 2, ...
著者Skerlova, J, Rezacova, P, Brynda, J.
登録日2019-04-24
公開日2020-07-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献CDK2/cyclin A2 in complex with open-ring 5-nitrosopyrimidine inhibitor LC436
To Be Published
1JST
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PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CYCLIN A, CYCLIN-DEPENDENT KINASE-2, ...
著者Russo, A.A, Jeffrey, P.D, Pavletich, N.P.
登録日1996-07-03
公開日1997-01-11
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis of cyclin-dependent kinase activation by phosphorylation.
Nat.Struct.Biol., 3, 1996
1JSU
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P27(KIP1)/CYCLIN A/CDK2 COMPLEX
分子名称: CYCLIN A, CYCLIN-DEPENDENT KINASE-2, P27, ...
著者Russo, A.A, Jeffrey, P.D, Pavletich, N.P.
登録日1996-07-03
公開日1997-07-29
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Nature, 382, 1996
5HQ0
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Ternary complex of human proteins CDK1, Cyclin B and CKS2, bound to an inhibitor
分子名称: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ...
著者Noble, M.E, Martin, M.P, Korolchuk, S, Brown, N.R, Moukhametzianov, R, Stanley, W.A.
登録日2016-01-21
公開日2016-03-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
5IF1
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Crystal structure apo CDK2/cyclin A
分子名称: Cyclin-A2, Cyclin-dependent kinase 2
著者Ayaz, P, Andres, D, Kwiatkowski, D.A, Kolbe, C, Lienau, P, Siemeister, G, Luecking, U, Stegmann, C.M.
登録日2016-02-25
公開日2016-04-27
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9.
Acs Chem.Biol., 11, 2016
8BYA
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Cryo-EM structure of SKP1-SKP2-CKS1-CDK2-CyclinA-p27KIP1 Complex
分子名称: Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, ...
著者Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E.
登録日2022-12-12
公開日2023-06-28
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1.
Sci Rep, 13, 2023
8B54
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CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR6768
分子名称: 1,2-ETHANEDIOL, Cyclin-A2, Cyclin-dependent kinase 2, ...
著者Djukic, S, Skerlova, J, Rezacova, P.
登録日2022-09-21
公開日2023-03-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7.
Biomed Pharmacother, 161, 2023
8H6T
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Complex structure of CDK2/Cyclin E1 and a potent, selective small molecule inhibitor
分子名称: (1R,3S)-3-{3-[(pyridin-2-yl)amino]-1H-pyrazol-5-yl}cyclopentyl propan-2-ylcarbamate, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1
著者Ren, X.
登録日2022-10-18
公開日2023-02-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design.
Acs Med.Chem.Lett., 14, 2023

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