7QHL

Crystal structure of Cyclin-dependent kinase 2/cyclin A in complex with 3,5,7-Substituted pyrazolo[4,3-d]pyrimidine inhibitor 24

Summary for 7QHL

• Entry DOI: 10.2210/pdb7qhl/pdb
• Descriptor: Cyclin-dependent kinase 2, Cyclin-A2, 5-(2-amino-1-ethyl)thio-3-cyclobutyl-7-[4-(pyrazol-1-yl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidine, ... (8 entities in total)
• Functional Keywords: cyclin-dependent kinase, inhibitor, pyrazolo[4, 3-d]pyrimidine, cell cycle
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 129576.19

Authors

Djukic, S.,Skerlova, J.,Rezacova, P. (deposition date: 2021-12-13, release date: 2022-07-06, Last modification date: 2024-01-31)

• Primary citation: Jorda, R.,Havlicek, L.,Perina, M.,Vojackova, V.,Pospisil, T.,Djukic, S.,Skerlova, J.,Gruz, J.,Renesova, N.,Klener, P.,Rezacova, P.,Strnad, M.,Krystof, V.; 3,5,7-Substituted Pyrazolo[4,3- d ]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.; J.Med.Chem., 65:8881-8896, 2022; PubMed: 35749742; DOI: 10.1021/acs.jmedchem.1c02184

Experimental method

X-RAY DIFFRACTION (1.7 Å)