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3TNW

Structure of CDK2/cyclin A in complex with CAN508

Summary for 3TNW
Entry DOI10.2210/pdb3tnw/pdb
DescriptorCyclin-dependent kinase 2, Cyclin-A2, 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, ... (5 entities in total)
Functional Keywordscyclin dependent kinase, kinase cyclin, phosphotransferase, cyclin a, phosphorylation at cdk2 threonine 160, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm, cytoskeleton, centrosome: P24941
Nucleus: P30274
Total number of polymer chains4
Total formula weight128920.88
Authors
Baumli, S.,Hole, A.J.,Endicott, J.A. (deposition date: 2011-09-02, release date: 2012-02-15, Last modification date: 2023-09-13)
Primary citationBaumli, S.,Hole, A.J.,Noble, M.E.,Endicott, J.A.
The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
Acs Chem.Biol., 7:811-816, 2012
Cited by
PubMed: 22292676
DOI: 10.1021/cb2004516
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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