3TNW
Structure of CDK2/cyclin A in complex with CAN508
Summary for 3TNW
Entry DOI | 10.2210/pdb3tnw/pdb |
Descriptor | Cyclin-dependent kinase 2, Cyclin-A2, 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, ... (5 entities in total) |
Functional Keywords | cyclin dependent kinase, kinase cyclin, phosphotransferase, cyclin a, phosphorylation at cdk2 threonine 160, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm, cytoskeleton, centrosome: P24941 Nucleus: P30274 |
Total number of polymer chains | 4 |
Total formula weight | 128920.88 |
Authors | Baumli, S.,Hole, A.J.,Endicott, J.A. (deposition date: 2011-09-02, release date: 2012-02-15, Last modification date: 2023-09-13) |
Primary citation | Baumli, S.,Hole, A.J.,Noble, M.E.,Endicott, J.A. The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508. Acs Chem.Biol., 7:811-816, 2012 Cited by PubMed: 22292676DOI: 10.1021/cb2004516 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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