5LQF
CDK1/CyclinB1/CKS2 in complex with NU6102
Summary for 5LQF
Entry DOI | 10.2210/pdb5lqf/pdb |
Descriptor | Cyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1, Cyclin-dependent kinases regulatory subunit 2, ... (5 entities in total) |
Functional Keywords | cdk1 cyclin b cks2 cell cycle nu6102, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: P06493 Cytoplasm: P14635 |
Total number of polymer chains | 6 |
Total formula weight | 153233.71 |
Authors | Coxon, C.R.,Anscombe, E.,Harnor, S.J.,Martin, M.P.,Carbain, B.J.,Hardcastle, I.R.,Harlow, L.K.,Korolchuk, S.,Matheson, C.J.,Noble, M.E.,Newell, D.R.,Turner, D.M.,Sivaprakasam, M.,Wang, L.Z.,Wong, C.,Golding, B.T.,Griffin, R.J.,Endicott, J.A.,Cano, C. (deposition date: 2016-08-17, release date: 2017-01-11, Last modification date: 2024-01-10) |
Primary citation | Coxon, C.R.,Anscombe, E.,Harnor, S.J.,Martin, M.P.,Carbain, B.,Golding, B.T.,Hardcastle, I.R.,Harlow, L.K.,Korolchuk, S.,Matheson, C.J.,Newell, D.R.,Noble, M.E.,Sivaprakasam, M.,Tudhope, S.J.,Turner, D.M.,Wang, L.Z.,Wedge, S.R.,Wong, C.,Griffin, R.J.,Endicott, J.A.,Cano, C. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J. Med. Chem., 60:1746-1767, 2017 Cited by PubMed: 28005359DOI: 10.1021/acs.jmedchem.6b01254 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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