5LQF

CDK1/CyclinB1/CKS2 in complex with NU6102

Summary for 5LQF

DescriptorCyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1, Cyclin-dependent kinases regulatory subunit 2, ... (5 entities in total)
Functional Keywordscdk1 cyclin b cks2 cell cycle nu6102, transferase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus P06493
Cytoplasm P14635
Total number of polymer chains6
Total molecular weight153233.71
Authors
Primary citation
Coxon, C.R.,Anscombe, E.,Harnor, S.J.,Martin, M.P.,Carbain, B.,Golding, B.T.,Hardcastle, I.R.,Harlow, L.K.,Korolchuk, S.,Matheson, C.J.,Newell, D.R.,Noble, M.E.,Sivaprakasam, M.,Tudhope, S.J.,Turner, D.M.,Wang, L.Z.,Wedge, S.R.,Wong, C.,Griffin, R.J.,Endicott, J.A.,Cano, C.
Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.
J. Med. Chem., 60:1746-1767, 2017
PubMed: 28005359 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.6b01254
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.06 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25550.3%6.6%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5lqf
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Molmil generated image of 5lqf
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Molmil generated image of 5lqf
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More Biological unit images

Molmil generated image of 5lqf
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Molmil generated image of 5lqf
rotated about x axis by 90°
Molmil generated image of 5lqf
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5lqf.pdb1.gz [221.06 KB])
Coordinate files for Biological unit (5lqf.pdb2.gz [220.95 KB])