7KJS
Crystal structure of CDK2/cyclin E in complex with PF-06873600
Summary for 7KJS
Entry DOI | 10.2210/pdb7kjs/pdb |
Descriptor | Cyclin-dependent kinase 2, G1/S-specific cyclin-E1, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, ... (4 entities in total) |
Functional Keywords | kinase inhibitor, cell cycle |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 68376.34 |
Authors | McTigue, M.A.,He, Y.,Ferre, R.A. (deposition date: 2020-10-26, release date: 2021-06-23, Last modification date: 2023-10-18) |
Primary citation | Freeman-Cook, K.D.,Hoffman, R.L.,Behenna, D.C.,Boras, B.,Carelli, J.,Diehl, W.,Ferre, R.A.,He, Y.A.,Hui, A.,Huang, B.,Huser, N.,Jones, R.,Kephart, S.E.,Lapek, J.,McTigue, M.,Miller, N.,Murray, B.W.,Nagata, A.,Nguyen, L.,Niessen, S.,Ninkovic, S.,O'Doherty, I.,Ornelas, M.A.,Solowiej, J.,Sutton, S.C.,Tran, K.,Tseng, E.,Visswanathan, R.,Xu, M.,Zehnder, L.,Zhang, Q.,Zhang, C.,Dann, S. Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J.Med.Chem., 64:9056-9077, 2021 Cited by PubMed: 34110834DOI: 10.1021/acs.jmedchem.1c00159 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.187 Å) |
Structure validation
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