7KJS

Crystal structure of CDK2/cyclin E in complex with PF-06873600

Summary for 7KJS

• Entry DOI: 10.2210/pdb7kjs/pdb
• Descriptor: Cyclin-dependent kinase 2, G1/S-specific cyclin-E1, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, ... (4 entities in total)
• Functional Keywords: kinase inhibitor, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 68376.34

Authors

McTigue, M.A.,He, Y.,Ferre, R.A. (deposition date: 2020-10-26, release date: 2021-06-23, Last modification date: 2023-10-18)

• Primary citation: Freeman-Cook, K.D.,Hoffman, R.L.,Behenna, D.C.,Boras, B.,Carelli, J.,Diehl, W.,Ferre, R.A.,He, Y.A.,Hui, A.,Huang, B.,Huser, N.,Jones, R.,Kephart, S.E.,Lapek, J.,McTigue, M.,Miller, N.,Murray, B.W.,Nagata, A.,Nguyen, L.,Niessen, S.,Ninkovic, S.,O'Doherty, I.,Ornelas, M.A.,Solowiej, J.,Sutton, S.C.,Tran, K.,Tseng, E.,Visswanathan, R.,Xu, M.,Zehnder, L.,Zhang, Q.,Zhang, C.,Dann, S.; Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.; J.Med.Chem., 64:9056-9077, 2021; PubMed: 34110834; DOI: 10.1021/acs.jmedchem.1c00159

Experimental method

X-RAY DIFFRACTION (2.187 Å)