7KJS
Crystal structure of CDK2/cyclin E in complex with PF-06873600
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 2 | polymer | 298 | 34056.5 | 1 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (Human) | Cell division protein kinase 2,p33 protein kinase |
| 2 | B (B) | G1/S-specific cyclin-E1 | polymer | 291 | 33848.3 | 1 | UniProt (P24864) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (Human) | |
| 3 | C (A) | 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one | non-polymer | 471.5 | 1 | Chemie (WG1) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
B: 81 - 363 (UniProt: P24864)
| PDB | External Database | Details |
|---|---|---|
| Glu 73 | - | expression tag |
| Asn 74 | - | expression tag |
| Leu 75 | - | expression tag |
| Tyr 76 | - | expression tag |
| Phe 77 | - | expression tag |
| Gln 78 | - | expression tag |
| Gly 79 | - | expression tag |
| Ser 80 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67904.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 471.5 | |
| All* | Total formula weight | 68376.3 |
