5CYI
CDK2/Cyclin A covalent complex with 6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine (NU6300)
Summary for 5CYI
Entry DOI | 10.2210/pdb5cyi/pdb |
Descriptor | Cyclin-dependent kinase 2, Cyclin-A2, 6-(cyclohexylmethoxy)-N-[4-(ethylsulfonyl)phenyl]-9H-purin-2-amine, ... (4 entities in total) |
Functional Keywords | cdk2 cyclin a covalent inhibitor vinylsulphone, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 Nucleus : P20248 |
Total number of polymer chains | 4 |
Total formula weight | 129536.08 |
Authors | Anscombe, E.,Meschini, E.,Vidal, R.M.,Martin, M.P.,Staunton, D.,Geitmann, M.,Danielson, U.H.,Stanley, W.A.,Wang, L.Z.,Reuillon, T.,Golding, B.T.,Cano, C.,Newell, D.R.,Noble, M.E.M.,Wedge, S.R.,Endicott, J.A.,Griffin, R.J. (deposition date: 2015-07-30, release date: 2015-09-16, Last modification date: 2024-01-10) |
Primary citation | Anscombe, E.,Meschini, E.,Mora-Vidal, R.,Martin, M.P.,Staunton, D.,Geitmann, M.,Danielson, U.H.,Stanley, W.A.,Wang, L.Z.,Reuillon, T.,Golding, B.T.,Cano, C.,Newell, D.R.,Noble, M.E.,Wedge, S.R.,Endicott, J.A.,Griffin, R.J. Identification and Characterization of an Irreversible Inhibitor of CDK2. Chem.Biol., 22:1159-1164, 2015 Cited by PubMed: 26320860DOI: 10.1016/j.chembiol.2015.07.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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